Evidence map›Paper›PMID 28583116›Full record

Trial reportBMC neurology2017

Association between total-Tau and brain atrophy one year after first-ever stroke.

Hege Ihle-Hansen, Guri Hagberg, Brynjar Fure, Bente Thommessen, Morten W Fagerland, Anne R Øksengård, Knut Engedal, Per Selnes

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00506818 (Cognitive and Emotional Impairment After Stroke), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00506818 nacompletednot on this map

Cognitive and Emotional Impairment After Stroke

TypeinterventionalSponsorSykehuset Asker og BaerumRan2007 to 2009Enrolled250ConditionsStroke, Cognitive Impairment, Vascular DementiaArmsMultifactorial vascular-risk-factor-intervention
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2019
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hege Ihle-HansenDepartment of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway. hege.ihle-hansen@vestreviken.no.
Guri HagbergDepartment of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway.
Brynjar FureNorwegian Knowledge Centre for the Health Services, Oslo, Norway.
Bente ThommessenDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Morten W FagerlandUnit of Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Anne R ØksengårdDepartment of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway.
Knut EngedalNorwegian Centre for Dementia Research, Oslo University Hospital, Oslo, Norway.
Per SelnesDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) and phosphorylated microtubule-associated protein tau indicate neurofibrillary degeneration. We aimed to explore the association between CSF T-tau and brain atrophy 1 year post-stroke.

methodsWe included 210 patients with first-ever ischemic stroke or transitory ischemic attack without pre-existing cognitive impairment. After 12 months, subjects underwent MRI, and CSF biomarkers were assessed. Using SIENAX (part of FSL), ventricular CSF volume and total brain volume were estimated and normalized for subject head size. The association between T-tau as explanatory variable and ventricular and total brain volume as outcome variables were studied using linear regression.

resultsOne hundred eighty-two patients completed the follow-up. Forty-four had a lumbar puncture. Of these, 31 had their MRI with identical scan parameters. Mean age was 70.2 years (SD 11.7). Ventricular volume on MRI was significantly associated with age, but not with gender. In the multiple regression model, there was a significant association between T-tau and both ventricular (beta 0.44, 95% CI 376.3, 394.9, p = 0.021) and global brain volume (beta -0.50, 95% CI -565.9, -78.3, p = 0.011). There was no significant association between CSF T-tau 1 year post-stroke and baseline volumes.

conclusionT-tau measured 1 year post-stroke is associated with measures of brain atrophy. The findings indicate that acute stroke may enhance or trigger tau-linked neurodegeneration with loss of neurons.

trial registrationClinicaltrials.gov NCT00506818 , July 23, 2007. Inclusion from February 2007, randomization and intervention from May 2007 and trial registration in July 2007.

Indexed as

Magnetic Resonance ImagingAgedAged, 80 and overAtrophyBiomarkersBrainFemaleFollow-Up StudiesHumansMaleMiddle AgedMultivariate AnalysisNeurodegenerative DiseasesNeurofibrillary TanglesStroketau ProteinsBiomarkerstau ProteinsCerebral spinal fluidNeurodegenerationStroke

Identifiers

PMID28583116
PMCPMC5460365

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.