Evidence map›Paper›PMID 28582607›Full record

Trial reportCancer science2017

Phase II study of intrabone single unit cord blood transplantation for hematological malignancies.

Makoto Murata, Yoshinobu Maeda, Masayoshi Masuko, Yasushi Onishi, Tomoyuki Endo, Seitaro Terakura, Yuichi Ishikawa, Chisako Iriyama, Yoko Ushijima, Tatsunori Goto and 12 more

Abstract readClinical Trial, Phase II
In one paragraph

Trial report in Cancer science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Makoto MurataDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0001-5488-4364
Yoshinobu MaedaDepartment of Hematology and Oncology, Okayama University, Okayama, Japan.
Masayoshi MasukoDepartment of Stem Cell Transplantation, Niigata University Hospital, Niigata, Japan.
Yasushi OnishiDepartment of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan.
Tomoyuki EndoDepartment of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Seitaro TerakuraDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuichi IshikawaDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Chisako IriyamaDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoko UshijimaDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tatsunori GotoDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nobuharu FujiiDepartment of Hematology and Oncology, Okayama University, Okayama, Japan.
Mitsune TanimotoDepartment of Hematology and Oncology, Okayama University, Okayama, Japan.
Hironori KobayashiDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Yasuhiko ShibasakiDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Noriko FukuharaDepartment of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan.
Yoshihiro InamotoDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ritsuro SuzukiDepartment of HSCT Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshihisa KoderaDepartment of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan.
Tadashi MatsushitaDepartment of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.
Hitoshi KiyoiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tomoki NaoeDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tetsuya NishidaDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outcomes of cord blood transplantation with non-irradiated reduced-intensity conditioning for hematological malignancies need to be improved because of graft failure and delayed engraftment. Intrabone infusion of cord blood cells has the potential to resolve the problems. In this phase II study, 21 adult patients with hematological malignancy received intrabone transplantation of serological HLA-A, B, and DR ≥4/6 matched single cord blood with a median number of cryopreserved total nucleated cells of 2.7 × 10

Indexed as

AdolescentAdultCord Blood Stem Cell TransplantationCryopreservationFemaleGraft vs Host DiseaseHematologic NeoplasmsHumansInjectionsMaleMiddle AgedNeutrophilsPlatelet CountReticulocyte CountSurvival AnalysisTransplantation ConditioningfludarabineVidarabineCord blood transplantationengraftmenthematological malignancyintrabonenon-myeloablative conditioning

Identifiers

PMID28582607
PMCPMC5543458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.