Evidence map›Paper›PMID 28582508›Full record

ArticleCarcinogenesis2017

Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.

Shengfeng Wang, Dezheng Huo, Temidayo O Ogundiran, Oladosu Ojengbede, Wei Zheng, Katherine L Nathanson, Barbara Nemesure, Stefan Ambs, Olufunmilayo I Olopade, Yonglan Zheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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  7. High-ThroughputFrontiers in oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Shengfeng WangDepartment of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA.
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Temidayo O OgundiranDepartment of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oladosu OjengbedeCenter for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
Katherine L NathansonDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Barbara NemesureDepartment of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA.
Stefan AmbsLaboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA.
Olufunmilayo I OlopadeTo whom correspondence should be addressed. Tel: +1 773 702 1632; Fax: +1 773 834 1659; Email: folopade@bsd.uchicago.edu
Yonglan ZhengTo whom correspondence should be addressed. Tel: +1 773 702 1632; Fax: +1 773 834 1659; Email: folopade@bsd.uchicago.eduORCID 0000-0001-9397-0409
Shell (Netherlands) · NLUniversity of Ibadan · NGChicago Department of Public Health · USNational Cancer Institute · USState University of New York · USUniversity of Chicago · USUniversity of Pennsylvania · USVanderbilt University · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Novel Markers for Disease Outcome in Breast CancerZIABC010887 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$11.5M
Using Genomics to Reduce Breast Cancer Disparities in the African DiasporaU01CA161032 · NCI · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2012 to 2015
$3.6M
Genome-wide association study of breast cancer in the African DiasporaR01CA142996 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2010 to 2012
$1.5M
NCI NIH HHS R01 CA142996NCI NIH HHS U01 CA161032NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Functional studies have elucidated the role of the mammalian target of rapamycin (mTOR) pathway in breast carcinogenesis, but to date, there is a paucity of data on its contribution to breast cancer risk in women of African ancestry. We examined 47628 SNPs in 61 mTOR pathway genes in the genome wide association study of breast cancer in the African Diaspora study (The Root consortium), which included 3686 participants (1657 cases). Pathway- and gene-level analyses were conducted using the adaptive rank truncated product (ARTP) test for 10994 SNPs that were not highly correlated (r2 < 0.8). Odds ratio (OR) and 95% confidence interval (CI) were estimated with logistic regression for each single-nucleotide polymorphism. The mTOR pathway was significantly associated with overall and estrogen receptor-negative (ER-) breast cancer risk (P = 0.003 and 0.03, respectively). PRKAG3 (Padj = 0.0018) and RPS6KA3 (Padj = 0.061) were the leading genes for the associations with overall breast cancer risk and ER- breast cancer risk, respectively. rs190843378 in PRKAG3 was statistically significant after gene-level adjustment for multiple comparisons (OR = 0.50 for each T allele, 95% CI = 0.38-0.66, Padj = 3.6E-05), with a statistical power of 0.914. These results provide new insights on the biological relevance of the mTOR pathway in breast cancer progression and underscore the need for more genetic epidemiology studies of breast cancer in the African Diaspora.

Indexed as

AllelesAMP-Activated Protein KinasesBlack PeopleBreast NeoplasmsCarcinogenesisEstrogen Receptor alphaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideRibosomal Protein S6 Kinases, 90-kDaSignal TransductionTOR Serine-Threonine KinasesAMP-Activated Protein KinasesESR1 protein, humanEstrogen Receptor alphaMTOR protein, humanPRKAG3 protein, humanribosomal protein S6 kinase, 90kDa, polypeptide 3Ribosomal Protein S6 Kinases, 90-kDaTOR Serine-Threonine Kinases

Identifiers

PMID28582508
PMCPMC5862308
OpenAlexW2621990096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.