ArticleBioinformatics (Oxford, England)2017
HUGIn: Hi-C Unifying Genomic Interrogator.
Article in Bioinformatics (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.The Lancet. Respiratory medicine · 2023Pooled it
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.Nature communications · 2019Pooled it
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.Nature genetics · 2018Pooled it
- Hi-C informed kernel association test for integrating 3D genome structure into variant-set analysis.Briefings in bioinformatics · 2026Article
- Hi-C informed kernel association test: integrating 3-dimensional genome structure into variant-set association for whole-genome sequencing data.bioRxiv : the preprint server for biology · 2025Article
- Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma.PLoS genetics · 2024Article
- A genome-wide association study of alloimmunization in the TOPMed OMG-SCD cohort identifies a locus on chromosome 12.Transfusion · 2024Article
- Post-GWAS functional analyses ofbioRxiv : the preprint server for biology · 2024Article
- Functional characterization of Alzheimer's disease genetic variants in microglia.Nature genetics · 2023Article
- The 3D genome and its impacts on human health and disease.Life medicine · 2023Review
- Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma.Frontiers in genetics · 2023Article
- A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.Scientific reports · 2022Article
- Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program.Nature communications · 2022Article
- Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization.Genes · 2022Review
- From GWAS variant to function: A study of ∼148,000 variants for blood cell traits.HGG advances · 2022Article
- Understanding the function of regulatory DNA interactions in the interpretation of non-coding GWAS variants.Frontiers in cell and developmental biology · 2022Review
- A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.Molecular psychiatry · 2021Article
- MUNIn: A statistical framework for identifying long-range chromatin interactions from multiple samples.HGG advances · 2021Article
- MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity.PLoS genetics · 2021Article
- HiC-ACT: improved detection of chromatin interactions from Hi-C data via aggregated Cauchy test.American journal of human genetics · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
motivationHigh throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.
resultsWe developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data. AVAILABILITY AND IMPLEMENTATION: HUGIn is available at http://yunliweb.its.unc.edu/HUGIn. CONTACT: yunli@med.unc.edu or hum@ccf.org. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.