ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function.Science advances · 2026Review
- Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function.Aging cell · 2025Article
- Aging reshapes the adaptive immune system from healer to saboteur.Nature aging · 2025Review
- Review
- Aging insights from heterochronic parabiosis models.npj aging · 2024Review
- Aging of lymphoid stromal architecture impacts immune responses.Seminars in immunology · 2023Review
- Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging.Seminars in immunology · 2023Review
- Review
- NF-κB, a culprit of both inflamm-ageing and declining immunity?Immunity & ageing : I & A · 2022Review
- Targeting TLR4 during vaccination boosts MAdCAM-1Science immunology · 2022Article
- Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites.Frontiers in immunology · 2022Article
- Review
- Infection-induced type I interferons critically modulate the homeostasis and function of CD8Nature communications · 2021Article
- Age-Related Changes in Thymic Central Tolerance.Frontiers in immunology · 2021Review
- Lymphoid stromal cells-more than just a highway to humoral immunity.Oxford open immunology · 2021Review
- Dynamic changes of T-lymphocyte subsets and the correlations with 89 patients with coronavirus disease 2019 (COVID-19).Annals of translational medicine · 2020Article
- Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.Aging cell · 2019Article
- Attrition of T Cell Zone Fibroblastic Reticular Cell Number and Function in Aged Spleens.ImmunoHorizons · 2018Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Age-related changes in primary lymphoid organs are well described. Less is known about age-related changes affecting peripheral lymphoid organs, although defects in old peripheral lymph nodes (pLNs) were recently described in both steady state and during viral infection. To address whether such pLN defects were intrinsic to old T cells or extrinsic (due to aging microenvironment), we employed heterochronic parabiosis. We found no age-related intrinsic or extrinsic barriers to T cell circulation and seeding of pLN, spleen, and bone marrow. However, heterochronic parabiosis failed to improve cellularity of old pLN, suggesting an environment-based limit on pLN cellularity. Furthermore, upon parabiosis, pLN of the adult partner exhibited reduced, old-like stromal and T cell cellularity, which was restored following separation of parabionts. Decay measurement of adult and old T cell subsets following separation of heterochronic parabionts delineated both T cell-intrinsic and environmental changes in T cell maintenance. Moreover, parabiotic separation revealed differences between CD4 and CD8 T cell subset maintenance with aging, the basis of which will require further investigation. Reasons for this asymmetric and subset-specific pattern of differential maintenance are discussed in light of possible age-related changes in lymph nodes as the key sites for peripheral T cell maintenance.
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