ArticlePLoS neglected tropical diseases2017
Transmission dynamics and control of Rickettsia rickettsii in populations of Hydrochoerus hydrochaeris and Amblyomma sculptum.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Assessment of tick populations associated with capybaras in natural reserves and human-modified environments with or without invasive plants in the state of São Paulo, Brazil.Experimental & applied acarology · 2026Article
- Effects of exposure to Rickettsia bellii on reservoir competence of guinea pigs for Rickettsia rickettsiiMemorias do Instituto Oswaldo Cruz · 2026Article
- Control ofInfectious Disease Modelling · 2025Article
- Experimental infection of wild boars (Sus scrofa) with Rickettsia rickettsii and evaluation of the transmission potential to Amblyomma sculptum ticks.Parasites & vectors · 2025Article
- A compartment and metapopulation model of Rocky Mountain spotted fever in southwestern United States and northern Mexico.Infectious Disease Modelling · 2024Article
- Survey of Rickettsia spp. in ticks (Acari: Ixodidae) infesting opossums (Didelphis albiventris) and capybaras (Hydrochoerus hydrochaeris) from an urban park in southeastern Brazil.Experimental & applied acarology · 2024Article
- Effect of environmental variables on the abundance of Amblyomma ticks, potential vectors of Rickettsia parkeri in central Brazil.PloS one · 2024Article
- Molecular detection of Babesia spp. and Rickettsia spp. in coatis (Nasua nasua) and associated ticks from midwestern Brazil.Parasitology research · 2023Article
- Comparing scapular morphology of Amblyomma sculptum and Amblyomma dubitatum nymphs allows a fast and practical differential diagnosis of ticks in highly infested areas with dominance of these two species.Experimental & applied acarology · 2022Article
- Serological exposure of spotted fever group Rickettsia in capybaras (Hydrochoerus hydrochaeris) from urban parks in Campo Grande, Brazilian Midwest.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Long-term persistence of anti-Rickettsia rickettsii antibodies in capybaras, with passive transfer to offspring.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2022Article
- Surgical sterilization of free-ranging capybaras (Animal reproduction · 2022Article
- Didelphis spp. opossums and their parasites in the Americas: A One Health perspective.Parasitology research · 2021Review
- Tick-borne zoonotic agents infecting horses from an urban area in Midwestern Brazil: epidemiological and hematological features.Tropical animal health and production · 2021Article
- Morphometric Patterns and Blood Biochemistry of Capybaras (Veterinary sciences · 2021Article
- Article
- Epidemiology of capybara-associated Brazilian spotted fever.PLoS neglected tropical diseases · 2019Article
- Comparative Susceptibility of Different Populations ofFrontiers in physiology · 2019Article
- Hosts mobility and spatial spread of Rickettsia rickettsii.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrazilian Spotted Fever (BSF), caused by the bacterium Rickettsia rickettsii, is the tick-borne disease that generates the largest number of human deaths in the world. In Brazil, the current increase of BSF human cases has been associated with the presence and expansion of capybaras Hydrochoerus hydrochaeris, which act as primary hosts for the tick Amblyomma sculptum, vector of the R. rickettsii in this area.
methodsWe proposed a semi-discrete-time stochastic model to evaluate the role of capybaras in the transmission dynamics of R. rickettsii. Through a sensitivity analysis, we identified the parameters with significant influence on the R. rickettsii establishment. Afterward, we implemented the Gillespie's algorithm to simulate the impact of potential public health interventions to prevent BSF human cases.
resultsThe introduction of a single infected capybara with at least one infected attached tick is enough to trigger the disease in a non-endemic area. We found that to avoid the formation of new BSF-endemic areas, it is crucial to impede the emigration of capybaras from endemic areas by reducing their birth rate by more than 58%. Model results were corroborated by ex-situ data generated from field studies, and this supports our proposal to prevent BSF human cases by implementing control strategies focused on capybaras.
conclusionThe proposed stochastic model illustrates how strategies for the control and prevention of vector-borne infectious diseases can be focused on amplifier hosts management practices. This work provides a basis for future prevention strategies for other neglected vector-borne diseases.
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