Evidence map›Paper›PMID 28582426›Full record

ArticlePloS one2017

Synthesis of a novel glucose capped gold nanoparticle as a better theranostic candidate.

Saritha Suvarna, Ujjal Das, Sunil Kc, Snehasis Mishra, Mathummal Sudarshan, Krishna Das Saha, Sanjit Dey, Anindita Chakraborty, Y Narayana

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 84 citations in OpenAlex.

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  7. Pharmaceutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Saritha SuvarnaDepartment of Studies in Physics, Mangalore University, Mangalagangotri, Karnataka, India.
Ujjal DasDepartment of Physiology, Centre for Nanoscience and Nanotechnology and Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, Kolkata, West Bengal, India.
Sunil KcDepartment of Studies in Physics, Mangalore University, Mangalagangotri, Karnataka, India.
Snehasis MishraCancer Biology & Inflammatory Disorder Division, IICB, Kolkata, West Bengal, India.
Mathummal SudarshanUGC-DAE Consortium for Scientific Research Centre, Kolkata, West Bengal, India.
Krishna Das SahaCancer Biology & Inflammatory Disorder Division, IICB, Kolkata, West Bengal, India.
Sanjit DeyDepartment of Physiology, Centre for Nanoscience and Nanotechnology and Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, Kolkata, West Bengal, India.
Anindita ChakrabortyUGC-DAE Consortium for Scientific Research Centre, Kolkata, West Bengal, India.
Y NarayanaDepartment of Studies in Physics, Mangalore University, Mangalagangotri, Karnataka, India.
Mangalore University · INIndian Institute of Chemical Biology · INUGC DAE Consortium for Scientific Research · INUniversity of Calcutta · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles are predominantly used in diagnostics, therapeutics and biomedical applications. The present study has been designed to synthesize differently capped gold nanoparticles (AuNps) by a simple, one-step, room temperature procedure and to evaluate the potential of these AuNps for biomedical applications. The AuNps are capped with glucose, 2-deoxy-D-glucose (2DG) and citrate using different reducing agents. This is the first report of synthesis of 2DG-AuNp by the simple room temperature method. The synthesized gold nanoparticles are characterized with UV-Visible Spectroscopy, Fourier transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM) and selected area electron diffraction (SAED), Dynamic light scattering (DLS), and Energy-dispersive X-ray spectroscopy (SEM-EDS). Surface-enhanced Raman scattering (SERS) study of the synthesized AuNps shows increase in Raman signals up to 50 times using 2DG. 3-(4, 5-dimethylthiozol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay has been performed using all the three differently capped AuNps in different cell lines to assess cytotoxcity if any, of the nanoparticles. The study shows that 2DG-AuNps is a better candidate for theranostic application.

Indexed as

Cell SurvivalCitric AcidDeoxyglucoseGlucoseGoldHCT116 CellsHeLa CellsHep G2 CellsHumansMetal NanoparticlesParticle SizeTheranostic NanomedicineCitric AcidDeoxyglucoseGlucoseGold

Identifiers

PMID28582426
PMCPMC5459428
OpenAlexW2623723222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.