ArticlePLoS neglected tropical diseases2017
Accuracy of parasitological and immunological tests for the screening of human schistosomiasis in immigrants and refugees from African countries: An approach with Latent Class Analysis.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Diagnosis and management of complicated urogenital schistosomiasis: a systematic review of the literature.Infection · 2023Pooled it
- Effectiveness of Screening and Treatment Approaches for Schistosomiasis and Strongyloidiasis in Newly-Arrived Migrants from Endemic Countries in the EU/EEA: A Systematic Review.International journal of environmental research and public health · 2018Pooled it
- Refining Diagnosis ofFrontiers in immunology · 2018Trial
- Trial
- Comparative performance of Kato-Katz, POC-CCA and real-time PCR in detecting Schistosoma mansoni infection at different endemicity settings in northwest Ethiopia: a cross-sectional study.Tropical medicine and health · 2025Article
- Evaluation of the recombinant proteinParasitology · 2025Article
- Home-Made Lateral Flow Test Strip Versus POC-CCA Assay for Detection of Active Schistosomiasis in Egypt.Acta parasitologica · 2024Article
- Comparative evaluation of plasma biomarkers of Schistosoma haematobium infection in endemic populations from Burkina Faso.PLoS neglected tropical diseases · 2024Article
- Review
- Pediatric urogenital schistosomiasis diagnosed in France.Pediatric nephrology (Berlin, Germany) · 2024Article
- Evaluation of Loop-Mediated Isothermal Amplification (LAMP) in Urine Samples for the Diagnosis of Imported Schistosomiasis.Tropical medicine and infectious disease · 2023Article
- Integration of female genital schistosomiasis into HIV/sexual and reproductive health and rights and neglected tropical diseases programmes and services: a scoping review.Sexual and reproductive health matters · 2023Article
- Review
- Spectrum of Helminth Infections in Migrants from Sub-Saharan Africa to Europe: A Literature Review.The American journal of tropical medicine and hygiene · 2023Review
- Evaluation of IL-35, as a Possible Biomarker for Follow-Up after Therapy, in Chronic HumanVaccines · 2023Article
- Accuracy of Three Serological Techniques for the Diagnosis of Imported Schistosomiasis in Real Clinical Practice: Not All in the Same Boat.Tropical medicine and infectious disease · 2023Article
- Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting.Tropical medicine and infectious disease · 2023Article
- Article
- Performance of a rapid immuno-chromatographic test (Schistosoma ICT IgG-IgM) for detecting Schistosoma-specific antibodies in sera of endemic and non-endemic populations.PLoS neglected tropical diseases · 2022Article
- Schistosomiasis Among Female Migrants in Non-endemic Countries: Neglected Among the Neglected? A Pilot Study.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchistosomiasis is a neglected infection affecting millions of people, mostly living in sub-Saharan Africa. Morbidity and mortality due to chronic infection are relevant, although schistosomiasis is often clinically silent. Different diagnostic tests have been implemented in order to improve screening and diagnosis, that traditionally rely on parasitological tests with low sensitivity. Aim of this study was to evaluate the accuracy of different tests for the screening of schistosomiasis in African migrants, in a non endemic setting. METHODOLOGY/PRINCIPAL
findingsA retrospective study was conducted on 373 patients screened at the Centre for Tropical Diseases (CTD) in Negrar, Verona, Italy. Biological samples were tested with: stool/urine microscopy, Circulating Cathodic Antigen (CCA) dipstick test, ELISA, Western blot, immune-chromatographic test (ICT). Test accuracy and predictive values of the immunological tests were assessed primarily on the basis of the results of microscopy (primary reference standard): ICT and WB resulted the test with highest sensitivity (94% and 92%, respectively), with a high NPV (98%). CCA showed the highest specificity (93%), but low sensitivity (48%). The analysis was conducted also using a composite reference standard, CRS (patients classified as infected in case of positive microscopy and/or at least 2 concordant positive immunological tests) and Latent Class Analysis (LCA). The latter two models demonstrated excellent agreement (Cohen's kappa: 0.92) for the classification of the results. In fact, they both confirmed ICT as the test with the highest sensitivity (96%) and NPV (97%), moreover PPV was reasonably good (78% and 72% according to CRS and LCA, respectively). ELISA resulted the most specific immunological test (over 99%). The ICT appears to be a suitable screening test, even when used alone.
conclusionsThe rapid test ICT was the most sensitive test, with the potential of being used as a single screening test for African migrants.
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