ArticleOrganic letters2017
Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer.RSC medicinal chemistry · 2024Article
- Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction?The Journal of organic chemistry · 2023Review
- Synthesis and In Vitro Evaluation of Gold Nanoparticles Functionalized with Thiol Ligands for Robust Radiolabeling withNanomaterials (Basel, Switzerland) · 2021Article
- Macrocyclization strategies for cyclic peptides and peptidomimetics.RSC medicinal chemistry · 2021Review
- Benchmark of Generic Shapes for Macrocycles.Journal of chemical information and modeling · 2020Article
- Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications.RSC advances · 2020Review
- Tubulysin Synthesis Featuring Stereoselective Catalysis and Highly Convergent Multicomponent Assembly.Organic letters · 2020Article
- Artificial Macrocycles.Synlett : accounts and rapid communications in synthetic organic chemistry · 2018Article
- Concise Synthesis of Macrocycles by Multicomponent Reactions.Synthesis · 2018Article
- Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions.Chemical science · 2018Article
- Concise Synthesis of Tetrazole Macrocycle.Organic letters · 2017Article
- Cysteine Isocyanide in Multicomponent Reaction: Synthesis of Peptido-Mimetic 1,3-Azoles.The Journal of organic chemistry · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization. The double-mercapto input is proposed for use in the Ugi reaction, thereby yielding all six topologically possible combinations. The protocol is convergent and short and enables the production of novel disulfide peptidomimetics in a highly general fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.