Evidence map›Paper›PMID 28581520›Full record

ArticleOncogene2017

KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the Kras

C-C Weng, J R Hawse, M Subramaniam, V H S Chang, W C Y Yu, W-C Hung, L-T Chen, K-H Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. SP and KLF Transcription Factors in Cancer Metabolism.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. KLF10 Deficiency in CD4Cell reports · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

C-C WengInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
J R HawseDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
M SubramaniamDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
V H S ChangProgram for Translation Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
W C Y YuNational Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
W-C HungNational Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
L-T ChenNational Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
K-H ChengInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
National Health Research Institutes · TWMayo Clinic in Arizona · USKaohsiung Medical University · TWNational Sun Yat-sen University · TWTaipei Medical University · TW

Funding

Role of a TGF-? Regulated Gene in Human and Mouse Osteoblasts and SkeletonR01DE014036 · NIDCR · MAYO CLINIC ROCHESTER · PI HAWSE, JOHN R., SUBRAMANIAM, MALAYANNAN · 2001 to 2016
$4.7M
NIDCR NIH HHS R01 DE014036
6 · The paper itself

Abstract

Krüppel-like transcription factor 10 (KLF10), also named as TIEG1, plays essential roles in mediating transforming growth factor beta (TGFβ) signaling and has been shown to function as a tumor suppressor in multiple cancer types. However, its roles in mediating cancer progression in vivo have yet to be fully characterized. Here, we have employed two well-characterized Pdx-1CreLSL-Kras

Indexed as

AnimalsCarcinoma, Pancreatic DuctalChemokine CXCL12Early Growth Response Transcription FactorsHumansKruppel-Like Transcription FactorsMiceMice, Inbred C57BLNeoplasm MetastasisPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Signal TransductionSurvival RateTumor Suppressor Protein p53Chemokine CXCL12Cxcl12 protein, mouseEarly Growth Response Transcription FactorsHras protein, mouseKLF10 protein, mouseKruppel-Like Transcription FactorsProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53

Identifiers

PMID28581520
OpenAlexW2621447334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.