Evidence map›Paper›PMID 28581518›Full record

ArticleOncogene2017

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.

S Sengupta, A Nagalingam, N Muniraj, M Y Bonner, P Mistriotis, A Afthinos, P Kuppusamy, D Lanoue, S Cho, P Korangath and 12 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Pan-Cancer Computational Analysis of RKIP (International journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. miRNAs as short non-coding RNAs in regulating doxorubicin resistance.Journal of cell communication and signaling · 2023
    Review
  12. Review
  13. Targeting Breast Cancer Stem Cells.International journal of biological sciences · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 3 countries.

S SenguptaDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
A NagalingamDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
N MunirajDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
M Y BonnerDepartment of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA, USA.
P MistriotisDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore MD, USA.
A AfthinosDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore MD, USA.
P KuppusamyDepartment of Medicine, University of Maryland School of Medicine, Baltimore MD, USA.
D LanoueDepartment of Biochemistry and Molecular Biology, Dalhousie University, Nova Scotia Canada.
S ChoDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
P KorangathDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
M ShriverDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
A BegumDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
V F MerinoDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
C-Y HuangDivision of Biostatistics and Bioinformatics, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
J L ArbiserDepartment of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA, USA.
W MatsuiDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
B GyőrffyMTA TTK Momentum Cancer Biomarker Research Group, Budapest, Hungary.
K KonstantopoulosDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore MD, USA.
S SukumarDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
P A MarignaniDepartment of Biochemistry and Molecular Biology, Dalhousie University, Nova Scotia Canada.
N K SaxenaDepartment of Medicine, University of Maryland School of Medicine, Baltimore MD, USA.
D SharmaDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD, USA.
Sidney Kimmel Comprehensive Cancer Center · USJohns Hopkins University · USDalhousie University · CAUniversity of Maryland, Baltimore · USEmory University · USSemmelweis University · HUWinship Cancer Institute

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Cutaneous Hemangiomas and Signal TransductionR01AR047901 · NIAMS · EMORY UNIVERSITY · PI ARBISER, JACK L · 2001 to 2018
$4.3M
TARGETING EXTRACELLULAR MATRIX-CANCER STEM CELL INTERACTIONS IN PANCREATIC CANCERR01CA193887 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI MATSUI, WILLIAM H · 2016 to 2021
$1.8M
Role of adipocytokines, leptin and adiponectin in breast carcinogenesisR01CA131294 · NCI · JOHNS HOPKINS UNIVERSITY · PI SHARMA, DIPALI · 2009 to 2014
$1.6M
MENTORING AND RESEARCH IN CANCER STEM CELLSK24CA198315 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI MATSUI, WILLIAM H · 2016 to 2020
$933k
Beneficial effects of Honokiol against liver cancerR21CA185943 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAXENA, NEERAJ KUMAR · 2015 to 2016
$395k
Inhibition of leptin-signaling axis in breast cancer by BITCR21CA155686 · NCI · JOHNS HOPKINS UNIVERSITY · PI SHARMA, DIPALI · 2014 to 2015
$388k
NCI NIH HHS K24 CA198315NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA131294NCI NIH HHS R01 CA193887NCI NIH HHS R21 CA155686NCI NIH HHS R21 CA185943NIAMS NIH HHS R01 AR047901
6 · The paper itself

Abstract

Tumor suppressor and upstream master kinase Liver kinase B1 (LKB1) plays a significant role in suppressing cancer growth and metastatic progression. We show that low-LKB1 expression significantly correlates with poor survival outcome in breast cancer. In line with this observation, loss-of-LKB1 rendered breast cancer cells highly migratory and invasive, attaining cancer stem cell-like phenotype. Accordingly, LKB1-null breast cancer cells exhibited an increased ability to form mammospheres and elevated expression of pluripotency-factors (Oct4, Nanog and Sox2), properties also observed in spontaneous tumors in Lkb1

Indexed as

Allyl CompoundsAMP-Activated Protein Kinase KinasesAnimalsBiphenyl CompoundsBreast NeoplasmsCell Line, TumorCell MovementCell Transformation, NeoplasticFemaleHumansLignansMiceNeoplastic Stem CellsPhenolsProtein Serine-Threonine KinasesSTAT3 Transcription FactorAllyl CompoundsAMP-Activated Protein Kinase KinasesBiphenyl CompoundshonokiolLignansPhenolsProtein Serine-Threonine KinasesSTAT3 protein, humanSTAT3 Transcription FactorSTK11 protein, human

Identifiers

PMID28581518
PMCPMC5793218
OpenAlexW2620975370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.