Evidence map›Paper›PMID 28581479›Full record

ArticleNature neuroscience2017

Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus.

Carlos A Campos, Anna J Bowen, Sung Han, Brent E Wisse, Richard D Palmiter, Michael W Schwartz

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 145 citations in OpenAlex.

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  13. Ingestion-activated CGRP neurons control learning but not satiety.bioRxiv : the preprint server for biology · 2025
    Article
  14. Neuroinflammation drives apathy in cancer cachexia.Cancer communications (London, England) · 2025
    Article
  15. Review
  16. Article
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carlos A CamposDepartment of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
Anna J BowenDepartment of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
Sung HanDepartment of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
Brent E WisseDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Richard D PalmiterDepartment of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
Michael W SchwartzDepartment of Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI MARAVILLA, KENNETH R · 2014 to 2019
$7.9M
Novel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6M
Effect of Killing or Removing GABA from NPY/AgRP NeuronsR01DA024908 · NIDA · UNIVERSITY OF WASHINGTON · PI PALMITER, RICHARD D. · 2007 to 2021
$3.5M
Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 SignalingR01DK101997 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2014 to 2018
$1.9M
Hypothalamic Inflammation and Energy HomeostasisR01DK090320 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2010 to 2014
$1.8M
(PQD6) Mechanistic insights into treatment of cancer anorexia and cachexiaR21CA184630 · NCI · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2014 to 2015
$416k
NCI NIH HHS R21 CA184630NICHD NIH HHS U54 HD083091NIDA NIH HHS R01 DA024908NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK083042NIDDK NIH HHS R01 DK090320NIDDK NIH HHS R01 DK101997
6 · The paper itself

Abstract

Anorexia is a common manifestation of chronic diseases, including cancer. Here we investigate the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) that transmit anorexic signals. We show that CGRP

Indexed as

Adenomatous Polyposis Coli ProteinAnimalsAnorexiaBehavior, AnimalBody WeightCachexiaCalcitonin Gene-Related PeptideCarcinoma, Lewis LungClozapineEnergy MetabolismFemaleIllness BehaviorMaleMetalloendopeptidasesMiceMice, TransgenicAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseCalca protein, mouseCalcitonin Gene-Related PeptideClozapineclozapine N-oxideMetalloendopeptidasesTetanus Toxinzinc-endopeptidase, tetanus neurotoxin

Identifiers

PMID28581479
PMCPMC5538581
OpenAlexW2623266097

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.