Observational studyHeadache2017
Clinical Characteristics and Treatment Patterns Among Patients Diagnosed With Cluster Headache in U.S. Healthcare Claims Data.
Observational study in Headache, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Cluster headache suicidality: a systematic review with a meta-analysis.The journal of headache and pain · 2025Pooled it
- Risks of suicide in migraine, non-migraine headache, back, and neck pain: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Family History of Cluster Headache: A Systematic Review.JAMA neurology · 2020Pooled it
- Sex differences in cluster headache: insights from the Chinese Cluster Headache Register Individual Study (CHRIS).The journal of headache and pain · 2026Observational
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- German language adaptation of the Cluster Headache Quality of Life Scale (CH-QoL).BMC neurology · 2024Article
- Managing Cluster Headache in Patients with Medical, Psychiatric, and Surgical Comorbidities.Current neurology and neuroscience reports · 2024Review
- The Prevalence and Clinical Phenotypes of Cluster Headache in Relation with Latitude.Current pain and headache reports · 2024Review
- Baseline demographics and disease characteristics of patients with episodic or chronic cluster headache: data from two phase 3 randomized clinical trials in Europe and North America.Frontiers in neurology · 2023Article
- Cluster Headache: Clinical Characteristics and Opportunities to Enhance Quality of Life.Current pain and headache reports · 2021Review
- The Opioid Epidemic and Primary Headache Disorders: A Nationwide Population-Based Study.Cureus · 2020Article
- The impact of remission and coexisting migraine on anxiety and depression in cluster headache.The journal of headache and pain · 2020Article
- Long-term efficacy of superficial temporal artery ligation and auriculotemporal nerve transection for temporal cluster headache in adolescent.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Behavioral and psychological aspects of cluster headache: an overview.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Emerging relevance of circadian rhythms in headaches and neuropathic pain.Acta physiologica (Oxford, England) · 2019Review
- Health Care Utilization and Direct Costs Among Patients Diagnosed with Cluster Headache in U.S. Health Care Claims Data.Journal of managed care & specialty pharmacy · 2018Observational
- Treatment of Cluster Headache.Annals of Indian Academy of Neurology · 2018Review
- Diagnoses of Cardiovascular Disease or Substance Addiction/Abuse in US Adults Treated for ADHD with Stimulants or Atomoxetine: Is Use Consistent with Product Labeling?Drugs - real world outcomes · 2018Article
- Treatment Strategies for the Opioid-Dependent Patient.Current pain and headache reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize demographics, clinical characteristics, and treatment patterns of patients with cluster headache (CH).
backgroundCH is an uncommon trigeminal autonomic cephalalgia with limited evidence-based treatment options. Patients suffer from extremely painful unilateral headache attacks and autonomic symptoms with episodic and chronic cycles. DESIGN/
methodsThis retrospective analysis used insurance claims from Truven Health Analytics MarketScan
resultsCH patients (N = 7589) were mainly male (57.4%) and 35-64 years old (73.2%), with significantly more claims for comorbid conditions vs controls (N = 30,341), including depressive disorders (19.8% vs 10.0%), sleep disturbances (19.7% vs 9.1%), anxiety disorders (19.2% vs 8.7%), and tobacco use disorders (12.8% vs 5.3%), with 2.5 times greater odds of suicidal ideation (all P < .0001). Odds of drug dependence were 3-fold greater among CH patients (OR = 2.8 [95% CI 2.3-3.4, P < .0001]). CH patients reported significantly greater use of prescription medications compared with controls; 25% of CH patients had >12 unique prescription drug claims. Most commonly prescribed drug classes for CH patients included: opiate agonists (41%), corticosteroids (34%), 5HT-1 agonists (32%), antidepressants (31%), NSAIDs (29%), anticonvulsants (28%), calcium antagonists (27%), and benzodiazepines (22%). Only 30.4% of CH patients received recognized CH treatments without opioids during the 12-month post-index period. These patients were less likely to visit emergency departments or need hospitalizations (26.8%) as compared to CH patients with no pharmacy claims for recognized CH treatments or opioids (33.6%; P < .0001).
conclusionsThe burden of CH is associated with significant co-morbidity, including substance use disorders and suicidal ideation, and treatment patterns indicating low use of recognized CH treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.