ArticleNature communications2017
Synergistic cooperation promotes multicellular performance and unicellular free-rider persistence.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Stochastic phenotypic switching arises in response to directional selection in experimentally evolved multicellular yeast.Communications biology · 2025Article
- Experimental evolution of multicellularity via cuboidal cell packing in fission yeast.Evolution letters · 2024Article
- Genomic sequencing reveals convergent adaptation during experimental evolution in two budding yeast species.Communications biology · 2024Article
- Multispecies interactions shape the transition to multicellularity.Proceedings. Biological sciences · 2023Article
- Bacteria evolve macroscopic multicellularity by the genetic assimilation of phenotypically plastic cell clustering.Nature communications · 2023Article
- Scalable Synthesis of Planar Macroscopic Lipid-Based Multi-Compartment Structures.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- The landscape of innovation in bacteria, battleships, and beyond.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Selection for synchronized cell division in simple multicellular organisms.Journal of theoretical biology · 2018Article
- Experimental evolution and proximate mechanisms in biology.Synthetic and systems biotechnology · 2017Review
- Developmental evolution facilitates rapid adaptation.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of multicellular life requires cooperation among cells, which can be undermined by intra-group selection for selfishness. Theory predicts that selection to avoid non-cooperators limits social interactions among non-relatives, yet previous evolution experiments suggest that intra-group conflict is an outcome, rather than a driver, of incipient multicellular life cycles. Here we report the evolution of multicellularity via two distinct mechanisms of group formation in the unicellular budding yeast Kluyveromyces lactis. Cells remain permanently attached following mitosis, giving rise to clonal clusters (staying together); clusters then reversibly assemble into social groups (coming together). Coming together amplifies the benefits of multicellularity and allows social clusters to collectively outperform solitary clusters. However, cooperation among non-relatives also permits fast-growing unicellular lineages to 'free-ride' during selection for increased size. Cooperation and competition for the benefits of multicellularity promote the stable coexistence of unicellular and multicellular genotypes, underscoring the importance of social and ecological context during the transition to multicellularity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.