ArticleNature communications2017
Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Single-cell transcriptome-wide Mendelian randomization during CD4Communications biology · 2026Article
- Deficiency of Aging-Related Gene Chitinase-Like 4 Impairs Olfactory Epithelium Homeostasis.Cell proliferation · 2025Article
- Cabergoline-induced NDFIP1 upregulation in pituitary neuroendocrine tumor cells activates mTOR signaling and contributes to cabergoline resistance.Journal of neuro-oncology · 2025Article
- Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent TNature neuroscience · 2025Article
- Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts.American journal of human genetics · 2025Article
- Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases.Frontiers in immunology · 2025Review
- The Ubiquitin Ligase Adaptor NDFIP1 Interacts with TRESK and Negatively Regulates the Background KInternational journal of molecular sciences · 2024Article
- Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.The Journal of clinical investigation · 2023Article
- Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Single-cell RNA sequencing reveals the transcriptomic characteristics of peripheral blood mononuclear cells in hepatitis B vaccine non-responders.Frontiers in immunology · 2023Article
- SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis.Cell death & disease · 2022Article
- SLC11A1 associated with tumor microenvironment is a potential biomarker of prognosis and immunotherapy efficacy for colorectal cancer.Frontiers in pharmacology · 2022Article
- Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues.Frontiers in immunology · 2022Review
- Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.Cell reports · 2021Article
- Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients.Scientific reports · 2021Article
- Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis.Frontiers in pharmacology · 2021Article
- CD4 T Helper Cell Subsets and Related Human Immunological Disorders.International journal of molecular sciences · 2020Review
- Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2 protein stability.European journal of immunology · 2020Article
- Itch regulation of innate and adaptive immune responses in mice and humans.Journal of leukocyte biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Awo Akosua Kesewa LaymanMedical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0001-9815-1445
Guoping DengCell Pathology Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Claire E O'LearyCell Pathology Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Samuel TadrosCell Pathology Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Rajan M ThomasDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Joseph M DybasDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Emily K MoserCell Pathology Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Andrew D WellsDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Nicolai M DolibaInstitute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Paula M OliverCell Pathology Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MNedd4-family adaptors and their regulation of T cell function.R01AI093566 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI OLIVER, PAULA MARIA · 2011 to 2020
$4.2MMechanisms of ubiquitin pathway activation and functionR01AI114515 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI OLIVER, PAULA MARIA · 2015 to 2019
$2.1MNCI NIH HHS T32 CA009140NIAID NIH HHS R01 AI093566NIAID NIH HHS R01 AI114515NIDDK NIH HHS P30 DK019525
Abstract
Foxp3
Indexed as
Signal TransductionAnimalsAntigen PresentationCarrier ProteinsCell MembraneCell ProliferationFemaleForkhead Transcription FactorsGlycolysisHyaluronan ReceptorsInflammationIntercellular Signaling Peptides and ProteinsInterleukin-4MaleMechanistic Target of Rapamycin Complex 1Membrane ProteinsCarrier ProteinsCd44 protein, mouseForkhead Transcription FactorsFoxp3 protein, mouseHyaluronan ReceptorsIntercellular Signaling Peptides and ProteinsInterleukin-4Mechanistic Target of Rapamycin Complex 1Membrane ProteinsNdfip1 protein, mouse
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.