ArticleNature communications2017
Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98 citing papers in PubMed, 219 citations in OpenAlex.
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- Neuronal protein Sex-lethal modulates tRNA synthesis via the polymerase III subunit Polr3E in male Drosophila neurons.PLoS biology · 2026Article
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- Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila.Nature metabolism · 2025Article
- Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025Review
- A memory transcriptome time course reveals essential long-term memory transcription factors.Nature communications · 2025Article
- Integrated Transcriptomic and Metabolomic Insights into "I See You" (ISY) Defensive Behavior inInsects · 2025Article
- A temporally restricted function of the dopamine receptor Dop1R2 during memory formation.eLife · 2025Article
- Two-point calibration protocol for the Förster Resonance Energy Transfer indicator Pyronic in neurons.Neurophotonics · 2025Article
- Neural Metabolic Networks: Key Elements of Healthy Brain Function.Journal of neurochemistry · 2025Review
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- How energy determines spatial localisation and copy number of molecules in neurons.Nature communications · 2025Article
- Astrocyte-to-neuron HNature metabolism · 2025Article
- Coordinating the energetic strategy of glia and neurons for memory.Trends in neurosciences · 2025Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient energy use has constrained the evolution of nervous systems. However, it is unresolved whether energy metabolism may resultantly regulate major brain functions. Our observation that Drosophila flies double their sucrose intake at an early stage of long-term memory formation initiated the investigation of how energy metabolism intervenes in this process. Cellular-resolution imaging of energy metabolism reveals a concurrent elevation of energy consumption in neurons of the mushroom body, the fly's major memory centre. Strikingly, upregulation of mushroom body energy flux is both necessary and sufficient to drive long-term memory formation. This effect is triggered by a specific pair of dopaminergic neurons afferent to the mushroom bodies, via the D5-like DAMB dopamine receptor. Hence, dopamine signalling mediates an energy switch in the mushroom body that controls long-term memory encoding. Our data thus point to an instructional role for energy flux in the execution of demanding higher brain functions.
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