ArticleActa crystallographica. Section D, Structural biology2017
Electron Bio-Imaging Centre (eBIC): the UK national research facility for biological electron microscopy.
Article in Acta crystallographica. Section D, Structural biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Systematic scale-up and enhanced purification of marine cyanophage P-SSP7.Frontiers in microbiology · 2026Article
- A service-based approach to cryoEM facility processing pipelines at eBIC.Acta crystallographica. Section D, Structural biology · 2024Article
- Scaling up cryo-EM for biology and chemistry: The journey from niche technology to mainstream method.Structure (London, England : 1993) · 2023Review
- Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases.Natural product reports · 2023Review
- Best practice: setting up and operating a mid-sized cryo-EM facility.Frontiers in molecular biosciences · 2023Article
- Application of super-resolution and correlative double sampling in cryo-electron microscopy.Faraday discussions · 2022Article
- Broadening access to cryoEM through centralized facilities.Trends in biochemical sciences · 2022Review
- The Hard X-ray Nanoprobe beamline at Diamond Light Source.Journal of synchrotron radiation · 2021Article
- Industrial cryo-EM facility setup and management.Acta crystallographica. Section D, Structural biology · 2020Article
- Machine learning and big scientific data.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets inIUCrJ · 2020Article
- CM01: a facility for cryo-electron microscopy at the European Synchrotron.Acta crystallographica. Section D, Structural biology · 2019Article
- Editorial: Technical Advances in Cryo-Electron Microscopy.Frontiers in molecular biosciences · 2019Article
- Using Scipion for stream image processing at Cryo-EM facilities.Journal of structural biology · 2018Article
- Where is crystallography going?Acta crystallographica. Section D, Structural biology · 2018Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The recent resolution revolution in cryo-EM has led to a massive increase in demand for both time on high-end cryo-electron microscopes and access to cryo-electron microscopy expertise. In anticipation of this demand, eBIC was set up at Diamond Light Source in collaboration with Birkbeck College London and the University of Oxford, and funded by the Wellcome Trust, the UK Medical Research Council (MRC) and the Biotechnology and Biological Sciences Research Council (BBSRC) to provide access to high-end equipment through peer review. eBIC is currently in its start-up phase and began by offering time on a single FEI Titan Krios microscope equipped with the latest generation of direct electron detectors from two manufacturers. Here, the current status and modes of access for potential users of eBIC are outlined. In the first year of operation, 222 d of microscope time were delivered to external research groups, with 95 visits in total, of which 53 were from unique groups. The data collected have generated multiple high- to intermediate-resolution structures (2.8-8 Å), ten of which have been published. A second Krios microscope is now in operation, with two more due to come online in 2017. In the next phase of growth of eBIC, in addition to more microscope time, new data-collection strategies and sample-preparation techniques will be made available to external user groups. Finally, all raw data are archived, and a metadata catalogue and automated pipelines for data analysis are being developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.