Evidence map›Paper›PMID 28580888›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Kinetic modelling of [

Mattia Veronese, Tiago Reis Marques, Peter S Bloomfield, Gaia Rizzo, Nisha Singh, Deborah Jones, Erjon Agushi, Dominic Mosses, Alessandra Bertoldo, Oliver Howes and 2 more

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. TSPO circadian pattern: a test-retest study of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Enhanced angiogenesis in the thalamus induced by a novel TSPO ligand ameliorates cognitive deficits after focal cortical infarction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Supervised clustering for TSPO PET imaging.European journal of nuclear medicine and molecular imaging · 2021
    Review
  16. Imaging of the glioma microenvironment by TSPO PET.European journal of nuclear medicine and molecular imaging · 2021
    Review
  17. Radiosynthesis and characterization of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  18. Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain.European journal of nuclear medicine and molecular imaging · 2021
    Review
  19. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Mattia Veronese1 Department of Neuroimaging, IoPPN, King's College London, London, UK.
Tiago Reis Marques2 Department of Psychosis Studies, IoPPN, King's College London, London, UK.
Peter S Bloomfield3 Institute of Clinical Sciences, Imperial College London, London, UK.
Gaia Rizzo4 Department of Information Engineering, Padova University, Padova, Italy.
Nisha Singh1 Department of Neuroimaging, IoPPN, King's College London, London, UK.
Deborah Jones5 Department of Cellular Pathology, Salford Royal Foundation Trust, Salford, UK.
Erjon Agushi6 Division of Neuroscience and Experimental Psychology, University of Manchester, UK.
Dominic Mosses6 Division of Neuroscience and Experimental Psychology, University of Manchester, UK.
Alessandra Bertoldo4 Department of Information Engineering, Padova University, Padova, Italy.
Oliver Howes2 Department of Psychosis Studies, IoPPN, King's College London, London, UK.
Federico Roncaroli6 Division of Neuroscience and Experimental Psychology, University of Manchester, UK.
Federico E Turkheimer1 Department of Neuroimaging, IoPPN, King's College London, London, UK.
King's College London · GBUniversity of Manchester · GBImperial College London · GBUniversity of Padua · ITSalford Royal NHS Foundation Trust · GB

Funding

Medical Research Council G0700995Medical Research Council G0900891Medical Research Council G1100809Medical Research Council MC_U120085814Medical Research Council MC_U120097115Medical Research Council MR/K022733/1Medical Research Council MR/N026063/1Medical Research Council MR/N026934/1Wellcome Trust
6 · The paper itself

Abstract

The 18 kDa translocator protein (TSPO) is a marker of microglia activation in the central nervous system and represents the main target of radiotracers for the in vivo quantification of neuroinflammation with positron emission tomography (PET). TSPO PET is methodologically challenging given the heterogeneous distribution of TSPO in blood and brain. Our previous studies with the TSPO tracers [

Indexed as

AcetamidesCerebellumFrontal LobeModels, NeurologicalPositron-Emission TomographyPurinesPyridinesAdministration, OralAdultHumansKineticsMaleMiddle AgedRadioactive TracersReceptors, GABAAcetamidesN-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamideN-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamidePurinesPyridinesRadioactive TracersReceptors, GABATSPO protein, human[11C]PBR283D modellingendotheliumimmunohistochemistrykinetic modellingTSPOXBD173

Identifiers

PMID28580888
PMCPMC6434448
OpenAlexW2621806352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.