SynthesisHuman brain mapping2017
Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 7 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.Biological psychiatry · 2023Pooled it
- Genetic variants associated with longitudinal changes in brain structure across the lifespan.Nature neuroscience · 2022Pooled it
- Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders.Molecular psychiatry · 2021Pooled it
- Genetic factors influencing a neurobiological substrate for psychiatric disorders.Translational psychiatry · 2021Pooled it
- [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Occupational Neuroplasticity in the Human Brain: A Critical Review and Meta-Analysis of Neuroimaging Studies.Frontiers in human neuroscience · 2020Pooled it
- Sleep as a moderator of adolescent brain development-evidence from a longitudinal MRI study.Sleep · 2026Article
- Timing and tempo of puberty and neurodevelopment following adversity: A registered report.Developmental cognitive neuroscience · 2026Article
- Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts.Annals of the New York Academy of Sciences · 2026Article
- Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes.bioRxiv : the preprint server for biology · 2026Article
- Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children.Nature communications · 2025Article
- Genetic and environmental influences on structural brain development from childhood to adolescence: A longitudinal twin study on cortical thickness, surface area, and subcortical volume.Developmental cognitive neuroscience · 2024Article
- Growing Up Together in Society (GUTS): A team science effort to predict societal trajectories in adolescence and young adulthood.Developmental cognitive neuroscience · 2024Article
- Aging Brain from a Lifespan Perspective.Current topics in behavioral neurosciences · 2024Review
- Heritability of cognitive and emotion processing during functional MRI in a twin sample.Human brain mapping · 2024Article
- New Challenges for Anatomists in the Era of Omics.Diagnostics (Basel, Switzerland) · 2023Review
- Genetic and Environmental Contributions to Subcortical Gray Matter Microstructure and Volume in the Developing Brain.Behavior genetics · 2023Article
- Sex- and Age-Specific Deviations in Cerebellar Structure and Their Link With Symptom Dimensions and Clinical Outcome in Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2023Article
- No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank.Translational psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 12 institutions in 3 countries.
Rachel M BrouwerDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-7466-1544
Matthew S PanizzonDepartment of Psychiatry, University of California, San Diego, California.
David C GlahnDepartment of Psychiatry, Yale University of Medicine, New Haven, Connecticut.ORCID 0000-0002-4749-6977
Derrek P HibarImaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Xue HuaImaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Neda JahanshadImaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Lucija AbramovicDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Greig I de ZubicarayInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, California.
Narelle K HansellQueensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.
Ian B HickieClinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Marinka M G KoenisDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-3859-3847
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Karen A MatherCentre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
Katie L McMahonCentre for Advanced Imaging, University of Queensland, St. Lucia, QLD, Australia.
Hugo G SchnackDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Lachlan T StrikeQueensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.
Suzanne C SwagermanDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
Wei WenCentre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
John H GilmoreDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina.
Nitin GogtayNational Institute of Mental Health, Bethesda, Maryland.
René S KahnDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Perminder S SachdevCentre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.ORCID 0000-0002-9595-3220
Margaret J WrightQueensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
William S KremenDepartment of Psychiatry, University of California, San Diego, California.
Paul M ThompsonImaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Hilleke E Hulshoff PolDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
University Medical Center Utrecht · NLMarina Del Rey Hospital · USThe University of Queensland · AUUNSW Sydney · AUUniversity of California San Diego · USVrije Universiteit Amsterdam · NLNational Institute of Mental Health · USQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AUThe University of Sydney · AUUniversity of North Carolina at Chapel Hill · USYale University · US
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MThe VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MThe VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MThe VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8MThe VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7MNeurodevelopment and Imaging among HIV-infected Children from the PREDICT studyR01MH089722 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALCOUR, VICTOR · 2010 to 2014
$3.1MSearching for Endophenotypes of Bipolar DisorderR01MH085667 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SOARES, JAIR C · 2012 to 2016
$3.0MGrowth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9MHARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6MEuropean Research Council 230374NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG040060NIA NIH HHS R01 AG050595NIA NIH HHS RF1 AG041915NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB008432NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH089722NIMH NIH HHS R01 MH094343NIMH NIH HHS R01 MH097268NINDS NIH HHS R01 NS080655
Abstract
Structural brain changes that occur during development and ageing are related to mental health and general cognitive functioning. Individuals differ in the extent to which their brain volumes change over time, but whether these differences can be attributed to differences in their genotypes has not been widely studied. Here we estimate heritability (h
Indexed as
Biological Variation, IndividualModels, GeneticQuantitative Trait, HeritableBrainGene-Environment InteractionHumansLongitudinal StudiesMagnetic Resonance ImagingModels, NeurologicalOrgan SizeTwin Studies as TopicENIGMA plasticity working groupheritabilityindividual brain plasticitylongitudinal magnetic resonance imagingtwins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.