Evidence map›Paper›PMID 28580455›Full record

Article... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics2017

Detection of Nuclei in H&E Stained Sections Using Convolutional Neural Networks.

Mina Khoshdeli, Richard Cong, Bahram Parvin

Abstract read
In one paragraph

Article in ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  6. Multi-Class Cell Detection Using Spatial Context Representation.Proceedings. IEEE International Conference on Computer Vision · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mina KhoshdeliBiomedical and Electrical Engineering Department, University of Nevada, Reno, NV, U.S.A.
Richard CongAmador Valley High School, Pleasanton, Ca, U.S.A.
Bahram ParvinBiomedical and Electrical Engineering Department, University of Nevada, Reno, NV, U.S.A.

Funding

High Content Representation and Association of 3D Cell Culture ModelsR01CA140663 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PARVIN, BAHRAM A. · 2011 to 2014
$2.4M
NCI NIH HHS R01 CA140663
6 · The paper itself

Abstract

Detection of nuclei is an important step in phenotypic profiling of histology sections that are usually imaged in bright field. However, nuclei can have multiple phenotypes, which are difficult to model. It is shown that convolutional neural networks (CNN)s can learn different phenotypic signatures for nuclear detection, and that the performance is improved with the feature-based representation of the original image. The feature-based representation utilizes Laplacian of Gaussian (LoG) filter, which accentuates blob-shape objects. Several combinations of input data representations are evaluated to show that by LoG representation, detection of nuclei is advanced. In addition, the efficacy of CNN for vesicular and hyperchromatic nuclei is evaluated. In particular, the frequency of detection of nuclei with the vesicular and apoptotic phenotypes is increased. The overall system has been evaluated against manually annotated nuclei and the F-Scores for alternative representations have been reported.

Identifiers

PMID28580455
PMCPMC5455148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.