Evidence map›Paper›PMID 28580453›Full record

ArticleEC microbiology2016

Reactive Oxygen Species in HIV Infection.

Jennifer Couret, Theresa L Chang

Open access · greenAbstract read
In one paragraph

Article in EC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. CD4Circulation · 2025
    Article
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  8. Article
  9. Article
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  12. Host mitochondria: more than an organelle in SARS-CoV-2 infection.Frontiers in cellular and infection microbiology · 2023
    Review
  13. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer CouretDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.
Theresa L ChangPublic Health Research Institute, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.
Rutgers, The State University of New Jersey · US

Funding

Modulation of innate immunity,microbiome and HIV transmission by Depo-ProveraR01AI110372 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHANG, THERESA L, YANG, LIYING · 2013 to 2017
$3.0M
NIAID NIH HHS R01 AI110372
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are a family of oxygen molecules with an unpaired electron and play an important role in homeostasis and pathogenesis. The reactive molecules modify lipids, proteins and nucleic acids, and modulate a wide range of cellular functions. The importance of ROS in infection has been established through clinical and in vitro studies. Here we review the role of oxidative stress in HIV pathogenesis, the impact of ROS on immune responses in HIV patients, and ROS-mediated regulation of HIV infection. Future studies on the interplay between ROS and HIV infection may offer a new strategy for prevention and treatment.

Indexed as

HIVImmune responseReactive oxygen species

Identifiers

PMID28580453
PMCPMC5450819
OpenAlexW3021422517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.