ArticleInternational journal of reproductive biomedicine2017
Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice.
Article in International journal of reproductive biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Paternal epigenetic inheritance increases susceptibility to methamphetamine taking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Methamphetamine-induced inhibition of Mettl21c in undifferentiated spermatogonia impairs male fertility in mice.Asian journal of andrology · 2026Article
- Mechanisms underlying methamphetamine-induced disruption of testicular integrity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Toxic Effects of Methamphetamine on Reproductive Systems, Embryo Development, and Newborns: An Evidence-based Review.Current medicinal chemistry · 2025Review
- METH exposure alters sperm DNA methylation in F0 mice and mPFC transcriptome in male F1 mice.Psychopharmacology · 2024Article
- Chronic Administration of Lisdexamfetamine Induces Apoptosis and Inflammation and Reduces Sperm Quality in Adult Male Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- An overview of the methamphetamine effect on male sexual behavior and reproductive system.Physiological research · 2023Review
- Reproductive status of male rat offspring following exposure to methamphetamine during intrauterine life: An experimental study.International journal of reproductive biomedicine · 2023Article
- Effect of melatonin on male offspring testis and sperm parameters in BALB/c mice after exposing their mother to METHamphetamine during pregnancy and lactation.Iranian journal of basic medical sciences · 2023Article
- Methamphetamine Downregulates the Sperm-Specific Calcium Channels Involved in Sperm Motility in Rats.ACS omega · 2022Article
- Impairment of sperm efficiency in mice following short-term nano-titanium dioxide exposure: An experimental study.International journal of reproductive biomedicine · 2021Article
- A systems omics-based approach to decode substance use disorders and neuroadaptations.Neuroscience and biobehavioral reviews · 2021Review
- Article
- The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3,4-Methylenedioxymethamphetamine Exposure in Adult Male Rats.Addiction & health · 2021Article
- Effects of acrylamide in the presence of vitamin E on sperm parameters, chromatin quality, and testosterone levels in mice.Clinical and experimental reproductive medicine · 2020Article
- Reduced Glycolysis Contributed to Inhibition of Testis Spermatogenesis in Rats After Chronic Methamphetamine Exposure.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effects of Methamphetamine on Testes Histopathology and Spermatogenesis Indices of Adult Male Rats.Addiction & health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMethamphetamine (MA) was shown to have harmful effects on male reproductive system.
objectiveTo investigate probable effects of daily administration of MA on sperm parameters and chromatin/DNA integrity in mouse. MATERIAL AND
methodsThirty-five NMRI male mice were divided into five groups including low, medium, and high dosage groups which were injected intraperitoneally with 4, 8 and 15 mg/kg/day for 35 days, respectively. Normal saline was injected in sham group and no medications were used in control group. Then, the mice were killed and caudal epididymis of each animal was cut and placed in Ham's F10 medium for sperm retrieval. To evaluate sperm chromatin abnormalities, the aniline blue, toluidine blue and chromomycine A3 were used. For sperm DNA integrity and apoptosis, the acridine orange, sperm chromatin dispersion, and TUNEL assay were applied. For sperm morphology, Papanicolaou staining was done.
resultsNormal morphology and progressive motility of spermatozoa decreased in medium and high dosage groups in comparison with the control group (p=0.035). There was a significant increase in rate of aniline blue, toluidine blue, and chromomycine A3 positive spermatozoa in high dosage group. In a similar manner, there was an increase in rates of acridine orange, TUNEL and sperm chromatin dispersion positive sperm cells in high dosage group with respect to others.
conclusionMA abuse in a dose-dependent manner could have detrimental effects on male reproductive indices including sperm parameters and sperm chromatin/DNA integrity in mice.
Indexed as
Identifiers
28580449PMC5447833W2612154994What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.