ArticleInternational journal of reproductive biomedicine2017
Protective effects of melatonin on testis histology following acute torsion-detorsion in rats.
Article in International journal of reproductive biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.Frontiers in endocrinology · 2023Pooled it
- Antioxidant Strategies in Testicular Ischemia-Reperfusion Injury-Translational Insights and Clinical Implications for Testicular Torsion Management.Antioxidants (Basel, Switzerland) · 2026Review
- Melatonin mitigates dichlorvos-induced derangements in the testes and epididymis of male Wistar rats.Animal reproduction · 2026Article
- Protective effects of melatonin against hypoxia-induced TM3 cell damage via suppression of the TGF-β pathway.Veterinary research forum : an international quarterly journal · 2026Article
- Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.Heliyon · 2024Review
- Varicocele and testicular cord torsion: immune testicular microenvironment imbalance.Frontiers in cell and developmental biology · 2023Review
- Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium.International journal of molecular sciences · 2022Article
- Cerium Oxide Nanoparticles Protect Cyclophosphamide-induced Testicular Toxicity in Mice.International journal of preventive medicine · 2019Article
- Article
- Probucol Reduces Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTesticular damage due to spermatic cord torsion may lead to infertility. It is probably because of changes in oxidative stress factors such as malondialdehyde.
objectiveTo investigate the protective effect of melatonin (MLT), as an antioxidant, on testicular damage induced by acute unilateral spermatic cord torsion and detorsion (T/D) in rats. MATERIALS AND
methodsIn this experimental study, 48 adult male Wistar rats were randomly divided into three groups (8 rats/group): sham group underwent right scrotal surgery only., the T/D group underwent right testicular torsion (for 1 hr) and detorsion, and the melatonin group underwent right testicular torsion, received 25 µg/kg melatonin intraperitoneally immediately after surgery of T/D. Then the histological parameters and malondialdehyde (MDA) changes were evaluated.
resultsTorsion and detorsion decreased the diameter of the tubules significantly compared to controls (p=0.003). Melatonin could increase the diameter, but it was not significant (p=0.26). The heights of the epithelium were constant in sham, T/D, and melatonin groups without any significant difference between groups (p=0.98). Based on Johnsen's score, spermatogenesis was normal in the sham group. The torsion significantly injured all lineage cells (p<0.001). There was no any spermatid or sperm in the seminiferous tubules. Melatonin improved the spermatogenesis significantly (p=0.02), but could not improve MDA level significantly (p=0.99).
conclusionSevere degenerative changes of testis were induced by acute unilateral spermatic cord torsion and detorsion in rats, but it had no effect on MDA level.
Indexed as
Identifiers
28580446PMC5447830W2612591851What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.