ArticleJournal of the Endocrine Society2017
Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women.
Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Metabolic and hepatic differences among biochemically euthyroid individuals with distinct thyroid hormone sources: a comparative study.BMC endocrine disorders · 2026Article
- Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- Hypothyroidism and Kidney Function: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2020Article
- Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.Thyroid : official journal of the American Thyroid Association · 2019Article
- Exercise training-induced changes in metabolic syndrome parameters, carotid wall thickness, and thyroid function in middle-aged women with subclinical hypothyroidism.Pflugers Archiv : European journal of physiology · 2019Article
- A cross-sectional cohort study with microvascular complications in patients with type 2 diabetes with and without hypothyroidism.Cardiovascular journal of AfricaObservational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
contextWhether subclinical hypothyroidism (SCH) is associated with cardiometabolic abnormalities is uncertain.
objectiveTo examine diverse cardiometabolic biomarkers across euthyroid, SCH, and overt hypothyroidism (HT) in women free of cardiovascular disease (CVD).
designCross-sectional adjusted associations for lipids, lipoprotein subclasses, lipoprotein insulin resistance score, inflammatory, coagulation, and glycemic biomarkers by ANCOVA for thyroid categories or TSH quintiles on a Women's Health Study subcohort.
settingOutpatient. PATIENTS OR OTHER
participantsRandomly sampled 3,914 middle-aged and older women for thyroid function analysis (thyroid-stimulating hormone [TSH], free T4), of whom 3,321 were not on lipid lowering therapy.
interventionNone.
main outcome measureAssociations of SCH and HT with cardiometabolic markers.
resultsGoing from euthyroid to HT, the lipoprotein subclasse profiles were indicative of insulin resistance [respective values and p for trend]: larger VLDL size (nm)[51.5 (95%CI51.2, 51.8) to 52.9 (51.8, 54.1) p=0.001]; higher LDL particles concentration (nmol/L)[1283 (95%CI1267, 1299) to 1358 (1298, 1418) p=0.004] and smaller LDL size. There was worsening lipoprotein insulin resistance score from euthyroid 49.2 (95%CI 48.3, 50.2) to SCH 52.1 (95%CI 50.1, 54.0), and HT 52.1 (95%CI 48.6, 55.6), p for trend 0.008. Of the other biomarkers, SCH and HT were associated with higher hs-CRP and HbA1c. For increasing TSH quintiles results were overall similar.
conclusionsIn apparently healthy women, SCH cardiometabolic profiles indicated worsening insulin resistance and higher CVD risk markers compared with euthyroid individuals, despite similar LDL and total cholesterol. These findings suggest that cardiometabolic risk may increase early in the progression towards SCH and OH.
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