Evidence map›Paper›PMID 28580363›Full record

ArticleHypoxia (Auckland, N.Z.)2017

Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine.

Katarzyna J Jerzak, Marissa Laureano, Radwa Elsharawi, Peter Kavsak, Kelvin Kw Chan, Sukhbinder K Dhesy-Thind, Kevin Zbuk

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypoxia (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Katarzyna J JerzakDepartment of Medicine, University of Toronto, Toronto, Ontario.
Marissa LaureanoDepartment of Medicine, McMaster University, Hamilton, Ontario.
Radwa ElsharawiDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario.
Peter KavsakDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario.
Kelvin Kw ChanSunnybrook Odette Cancer Centre, University of Toronto, Toronto.
Sukhbinder K Dhesy-ThindDepartment of Oncology, McMaster University, Hamilton, Ontario, Canada.
Kevin ZbukDepartment of Oncology, McMaster University, Hamilton, Ontario, Canada.
McMaster University · CASunnybrook Health Science Centre · CAImpact · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlycolytic markers have been detected in colorectal cancer (CRC) using advanced analytical methods.

methodsUsing commercially available assays, by-products of anaerobic metabolism were prospectively measured in the blood and urine of 20 patients with metastatic colorectal cancer (mCRC) and 20 patients with local disease. Twenty-four-hour urine citrate, plasma lactate, ketones, venous blood gas, anion gap, and osmolar gap were investigated. Results of patients with metastatic and local CRC were compared using two-sample

resultsThe average venous pCO

conclusionPatients with mCRC had higher venous pCO

Indexed as

biomarkercolorectal cancerhypoxiametabolismmetabolomicsvenous CO2

Identifiers

PMID28580363
PMCPMC5449104
OpenAlexW2618022781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.