ArticleNeuroImage. Clinical2017
Cortical gyrification is abnormal in children with prenatal alcohol exposure.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.Alcoholism, clinical and experimental research · 2021Trial
- Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026Review
- Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure.Journal of neurodevelopmental disorders · 2025Article
- Quantifying the Timing of Gyral and Sulcal Formation Relative to Growth in the Ferret Cerebral Cortex.Developmental neuroscience · 2025Article
- Multi-scale measurement of stiffness in the developing ferret brain.Scientific reports · 2023Article
- Fetal alcohol spectrum disorders prevention and clinical guidelines research-workshop report.BMC proceedings · 2023Article
- Delayed cortical thinning in children and adolescents with prenatal alcohol exposure.Alcohol, clinical & experimental research · 2023Article
- Impact of alcohol exposure on neural development and network formation in human cortical organoids.Molecular psychiatry · 2023Article
- Associations of gestational age with gyrification and neurocognition in healthy adults.European archives of psychiatry and clinical neuroscience · 2023Article
- Mapping corpus callosum surface reduction in fetal alcohol spectrum disorders with sulci and connectivity-based parcellation.Frontiers in neuroscience · 2023Article
- The impact of prenatal alcohol exposure on gray matter volume and cortical surface area of 2 to 3-year-old children in a South African birth cohort.Alcoholism, clinical and experimental research · 2022Article
- Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity.Molecular neurobiology · 2022Review
- Review
- Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure.Drug and alcohol dependence · 2021Article
- Association Between Socioeconomic Status and In Utero Fetal Brain Development.JAMA network open · 2021Article
- Neurodevelopmental Trajectories Following Prenatal Alcohol Exposure.Frontiers in human neuroscience · 2021Article
- Review
- Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Alcohol use in young adults associated with cortical gyrification.Drug and alcohol dependence · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesPrenatal alcohol exposure (PAE) adversely affects early brain development. Previous studies have shown a wide range of structural and functional abnormalities in children and adolescents with PAE. The current study adds to the existing literature specifically on cortical development by examining cortical gyrification in a large sample of children with PAE compared to controls. Relationships between cortical development and intellectual functioning are also examined. EXPERIMENTAL
designIncluded were 92 children with PAE and 83 controls ages 9-16 from four sites in the Collaborative Initiative on FASD (CIFASD). All PAE participants had documented heavy PAE. All underwent a formal evaluation of physical anomalies and dysmorphic facial features. MRI data were collected using modified matched protocols on three platforms (Siemens, GE, and Philips). Cortical gyrification was examined using a semi-automated procedure. PRINCIPAL OBSERVATIONS: Whole brain group comparisons using Monte Carlo z-simulation for multiple comparisons showed significantly lower cortical gyrification across a large proportion of the cerebral cortex amongst PAE compared to controls. Whole brain comparisons and ROI based analyses showed strong positive correlations between cortical gyrification and IQ (i.e. less developed cortex was associated with lower IQ).
conclusionsAbnormalities in cortical development were seen across the brain in children with PAE compared to controls. Cortical gyrification and IQ were strongly correlated, suggesting that examining mechanisms by which alcohol disrupts cortical formation may yield clinically relevant insights and potential directions for early intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.