Evidence map›Paper›PMID 28580282›Full record

ArticleMolecular metabolism2017

Hepatic gene therapy rescues high-fat diet responses in circadian

Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H Tsang, Johanna L Barclay, Henrik Oster

Open access · goldAbstract read
In one paragraph

Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.Trends in endocrinology and metabolism: TEM · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Judit Meyer-KovacCircadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Isa KolbeChronophysiology Group, Medical Department 1, University of Lübeck, Lübeck, Germany.
Lea EhrhardtCircadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Alexei LeliavskiChronophysiology Group, Medical Department 1, University of Lübeck, Lübeck, Germany.
Jana HusseCircadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Gabriela SalinasMicroarray and Deep-Sequencing Core Facility, Institute Developmental Biochemistry, University Medical Center, Göttingen, Germany.
Thomas LingnerMicroarray and Deep-Sequencing Core Facility, Institute Developmental Biochemistry, University Medical Center, Göttingen, Germany.
Anthony H TsangCircadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Johanna L BarclayMater Research Institute, University of Queensland, Brisbane, Australia.
Henrik OsterCircadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Max Planck Institute for Biophysical Chemistry · DEUniversitätsmedizin Göttingen · DEUniversity of Lübeck · DEThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCircadian

methodsMetabolic parameters of wild-type (WT) and

resultsNighttime-restricted feeding restored food intake, but not body weight regulation in MT mice under HFD, suggesting

conclusionLiver

Indexed as

Genetic TherapyAnimalsCLOCK ProteinsDiet, High-FatFeeding BehaviorHyperphagiaLiverMaleMiceMice, Inbred C57BLMutationObesityClock protein, mouseCLOCK ProteinsCircadian clockClock geneGene therapyHigh-fat dietLiverTranscription

Identifiers

PMID28580282
PMCPMC5444075
OpenAlexW2598650641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.