ArticleMass spectrometry (Tokyo, Japan)2017
Prediction of Hopeless Peptides Unlikely to be Selected for Targeted Proteome Analysis.
Article in Mass spectrometry (Tokyo, Japan), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Increased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis.Scientific reports · 2021Article
- Assessment of Protein Content and Phosphorylation Level inMolecules (Basel, Switzerland) · 2020Article
- Comparative Targeted Proteomics of the Central Metabolism and Photosystems in SigE Mutant Strains ofMolecules (Basel, Switzerland) · 2018Article
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Authors and funding
3 authors.
Funding
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Abstract
In targeted proteomics using liquid chromatography-tandem triple quadrupole mass spectrometry (LC/MS/MS) in the selected reaction monitoring (SRM) mode, selecting the best observable or visible peptides is a key step in the development of SRM assay methods of target proteins. A direct comparison of signal intensities among all candidate peptides by brute-force LC/MS/MS analysis is a concrete approach for peptide selection. However, the analysis requires an SRM method with hundreds of transitions. This study reports on the development of a method for predicting and identifying hopeless peptides to reduce the number of candidate peptides needed for brute-force experiments. Hopeless peptides are proteotypic peptides that are unlikely to be selected for targets in SRM analysis owing to their poor ionization characteristics. Targeted proteomics data from
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