ReviewAging and disease2017
Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases.
Review in Aging and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Comparative Evaluation of Metabolic Syndrome, Circadian Syndrome, and Allostatic Load Measures on All-Cause Mortality in U.S. Males and Females.International journal of endocrinology · 2026Article
- Proteins at the intersection of circadian rhythms and metabolic dysfunction-associated steatotic liver disease: an 18-protein panel as a novel predictive biomarker set.Frontiers in endocrinology · 2026Article
- Review
- Optimizing Radiotherapy Timing for Nasopharyngeal Carcinoma: The Impact of Radiation Scheduling on Survival.JCO precision oncology · 2025Article
- Global, regional, and national burden of cardiovascular disease attributable to high body mass index from 1990 to 2021 and projection to 2045.Frontiers in endocrinology · 2025Article
- The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies.Research (Washington, D.C.) · 2025Review
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Impact of the radiotherapy rhythm on prognosis in nasopharyngeal carcinoma.Annals of medicine · 2024Article
- Age-related liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit.Nature aging · 2023Article
- The influence of circadian rhythms and aerobic glycolysis in autism spectrum disorder.Translational psychiatry · 2020Review
- E3 ubiquitin ligase HRD1 modulates the circadian clock through regulation of BMAL1 stability.Experimental and therapeutic medicine · 2020Article
- Article
- Antithrombin III expression predicts acute kidney injury in elderly patients with sepsis.Experimental and therapeutic medicine · 2020Article
- Circadian Rhythms in Exudative Age-Related Macular Degeneration: The Key Role of the Canonical WNT/β-Catenin Pathway.International journal of molecular sciences · 2020Review
- Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival.Scientific reports · 2019Article
- Associations of sleep durations and sleep-related parameters with metabolic syndrome among older Chinese adults.Endocrine · 2019Article
- AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis.Aging and disease · 2019Article
- Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3.International journal of molecular sciences · 2018Review
- Urinary Neutrophil Gelatinase-Associated Lipocalin Is Excellent Predictor of Acute Kidney Injury in Septic Elderly Patients.Aging and disease · 2018Article
- Circadian and Metabolic Perspectives in the Role Played by NADPH in Cancer.Frontiers in endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating epidemiological studies have implicated a strong link between age associated metabolic diseases and cancer, though direct and irrefutable evidence is missing. In this review, we discuss the connection between Warburg effects and tumorigenesis, as well as adaptive responses to environment such as circadian rhythms on molecular pathways involved in metabolism. We also review the central role of the sirtuin family of proteins in physiological modulation of cellular processes and age-associated metabolic diseases. We also provide a macroscopic view of how the circadian rhythm affects metabolism and may be involved in cell metabolism reprogramming and cancer pathogenesis. The aberrations in metabolism and the circadian system may lead to age-associated diseases directly or through intermediates. These intermediates may be either mutated or reprogrammed, thus becoming responsible for chromatin modification and oncogene transcription. Integration of circadian rhythm and metabolic reprogramming in the holistic understanding of metabolic diseases and cancer may provide additional insights into human diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.