ArticleF1000Research2017
The elephant shark methylome reveals conservation of epigenetic regulation across jawed vertebrates.
Article in F1000Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Evolution and Spatiotemporal Expression ofJournal of developmental biology · 2024Article
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- Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.Science advances · 2022Article
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- Age group DNA methylation differences in lemon sharks (Ecology and evolution · 2022Article
- Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions.BMC genomics · 2022Article
- Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation.Epigenetics · 2021Article
- Cytosine methylation patterns suggest a role of methylation in plastic and adaptive responses to temperature in European grayling (Epigenetics · 2021Article
- The emergence of the brain non-CpG methylation system in vertebrates.Nature ecology & evolution · 2021Article
- A chicken DNA methylation clock for the prediction of broiler health.Communications biology · 2021Article
- Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation.Nature communications · 2019Article
- Stress, novel sex genes, and epigenetic reprogramming orchestrate socially controlled sex change.Science advances · 2019Article
- Bridging disciplines to advance elasmobranch conservation: applications of physiological ecology.Conservation physiology · 2019Article
- Evolutionary conservation of DNA methylation in CpG sites within ultraconserved noncoding elements.Epigenetics · 2018Article
- Molecular evolution of DNMT1 in vertebrates: Duplications in marsupials followed by positive selection.PloS one · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMethylation of CG dinucleotides constitutes a critical system of epigenetic memory in bony vertebrates, where it modulates gene expression and suppresses transposon activity. The genomes of studied vertebrates are pervasively hypermethylated, with the exception of regulatory elements such as transcription start sites (TSSs), where the presence of methylation is associated with gene silencing. This system is not found in the sparsely methylated genomes of invertebrates, and establishing how it arose during early vertebrate evolution is impeded by a paucity of epigenetic data from basal vertebrates.
methodsWe perform whole-genome bisulfite sequencing to generate the first genome-wide methylation profiles of a cartilaginous fish, the elephant shark
conclusionsOur demonstration that methylation patterns in a cartilaginous fish are characteristic of higher vertebrates imply the conservation of this epigenetic modification system across jawed vertebrates separated by 465 million years of evolution. In addition, these findings position the elephant shark as a valuable model to explore the evolutionary history and function of vertebrate methylation.
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