ArticleFrontiers in neuroscience2017
Chronic Ketamine Exposure Causes White Matter Microstructural Abnormalities in Adolescent Cynomolgus Monkeys.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review.Frontiers in neuroscience · 2025Review
- Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice.Frontiers in pharmacology · 2025Article
- White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development.Journal of neuroscience methods · 2024Article
- Oral ketamine may offer a solution to the ketamine conundrum.Psychopharmacology · 2023Review
- Neurobiological mechanisms and related clinical treatment of addiction: a review.Psychoradiology · 2022Review
- Ketamine use disorder: preclinical, clinical, and neuroimaging evidence to support proposed mechanisms of actions.Intelligent medicine · 2022Article
- Chronic administration of ketamine induces cognitive deterioration by restraining synaptic signaling.Molecular psychiatry · 2021Article
- LncRNA LINC00641 Sponges miR-497-5p to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF.Frontiers in molecular neuroscience · 2020Article
- Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youths on the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Miniature pig magnetic resonance spectroscopy model of normal adolescent brain development.Journal of neuroscience methods · 2018Article
- Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.Pharmacological reviews · 2018Review
- Miniature pig model of human adolescent brain white matter development.Journal of neuroscience methods · 2018Article
- Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute and repeated exposures to ketamine mimic aspects of positive, negative, and cognitive symptoms of schizophrenia in humans. Recent studies by our group and others have shown that chronicity of ketamine use may be a key element for establishing a more valid model of cognitive symptoms of schizophrenia. However, current understanding on the long-term consequences of ketamine exposure on brain circuits has remained incomplete, particularly with regard to microstructural changes of white matter tracts that underpin the neuropathology of schizophrenia. Thus, the present study aimed to expand on previous investigations by examining causal effects of repeated ketamine exposure on white matter integrity in a non-human primate model. Ketamine or saline (control) was administered intravenously for 3 months to male adolescent cynomolgus monkeys (
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