Evidence map›Paper›PMID 28579847›Full record

ArticleBiomarkers in cancer2017

Correlation Between Preoperative Serum Carcinoembryonic Antigen Levels and Expression on Pancreatic and Rectal Cancer Tissue.

L S F Boogerd, F A Vuijk, C E S Hoogstins, H J M Handgraaf, M J M van der Valk, P J K Kuppen, C F M Sier, C J H van de Velde, J Burggraaf, A Fariña-Sarasqueta and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Biomarkers in cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study.European journal of nuclear medicine and molecular imaging · 2024
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Translational molecular imaging in exocrine pancreatic cancer.European journal of nuclear medicine and molecular imaging · 2018
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

L S F BoogerdDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
F A VuijkDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
C E S HoogstinsDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
H J M HandgraafDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
M J M van der ValkDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
P J K KuppenDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
C F M SierDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
C J H van de VeldeDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
J BurggraafCentre for Human Drug Research, Leiden, The Netherlands.
A Fariña-SarasquetaDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Alexander L VahrmeijerDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLCentre for Human Drug Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinoembryonic antigen (CEA)-targeted imaging and therapeutic agents are being tested in clinical trials. If CEA overexpression in malignant tissue corresponds with elevated serum CEA, serum CEA could assist in selecting patients who may benefit from CEA-targeted agents. This study aims to assess the relationship between serum CEA and CEA expression in pancreatic (n = 20) and rectal cancer tissues (n = 35) using histopathology. According to local laboratory standards, a serum CEA >3 ng/mL was considered elevated. In pancreatic cancer patients a significant correlation between serum CEA and percentage of CEA-expressing tumor cells was observed (

Indexed as

biomarkerCEACAM5fluorescence imagingpancreasPancreatic ductal adenocarcinomarectum

Identifiers

PMID28579847
PMCPMC5437985
OpenAlexW2614915581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.