Evidence map›Paper›PMID 28579827›Full record

ReviewJournal of experimental neuroscience2017

Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity.

Cyril Eleftheriou, Fabrizia Cesca, Luca Maragliano, Fabio Benfenati, Jose Fernando Maya-Vetencourt

Abstract readReview
In one paragraph

Review in Journal of experimental neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cyril EleftheriouCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.
Fabrizia CescaCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.
Luca MaraglianoCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.
Fabio BenfenatiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.
Jose Fernando Maya-VetencourtCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several fields in neuroscience have been revolutionized by the advent of optogenetics, a technique that offers the possibility to modulate neuronal physiology in response to light stimulation. This innovative and far-reaching tool provided unprecedented spatial and temporal resolution to explore the activity of neural circuits underlying cognition and behaviour. With an exponential growth in the discovery and synthesis of new photosensitive actuators capable of modulating neuronal networks function, other fields in biology are experiencing a similar re-evolution. Here, we review the various optogenetic toolboxes developed to influence cellular physiology as well as the diverse ways in which these can be engineered to precisely modulate intracellular signalling and transcription. We also explore the processes required to successfully express and stimulate these photo-actuators

Indexed as

epigeneticsgene expressionintracellular signallingneuronal plasticityOptogeneticstranscription

Identifiers

PMID28579827
PMCPMC5415353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.