Evidence map›Paper›PMID 28579766›Full record

SynthesisClinical interventions in aging2017

Effects of multi-domain interventions in (pre)frail elderly on frailty, functional, and cognitive status: a systematic review.

Lenore Dedeyne, Mieke Deschodt, Sabine Verschueren, Jos Tournoy, Evelien Gielen

3 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 150 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 16 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05831982 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of a Complex Person-centered Exercise and Nutrition Intervention for Frail Older Patients on Functional Decline, Quality of Life and Readmissions - A Randomized Controlled Trial.

TypeinterventionalSponsorAalborg University HospitalRan2021 to 2023Enrolled119ConditionsFrailtyArmsPerson-centered strength training and nutrition intervention, Standard training
NCT06611228 narecruitingnot on this mapstarted 2024, after this paper: background citation

Optimizing Prevention of Hospital-acquired Disability Through Integrated Multidomain Interventions: the Age-IT Project

TypeinterventionalSponsorUniversity of Milano BicoccaRan2024 to 2027Enrolled288ConditionsFrailty Syndrome, AgingArmsMultidomain Interventions
NCT07027241 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients

TypeinterventionalSponsorRoyal College of Surgeons, IrelandRan2025 to 2026Enrolled50ConditionsHip Fractures (ICD-10 72.01-72.2), Frailty at Older Adults, Strength Training, Resistance TrainingArmsExercise Intervention, Usual Care, Nutritional Intervention
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 16 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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  12. Health-related quality of life and exercise-based cardiac rehabilitation in contemporary acute coronary syndrome patients: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
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  16. Atencion primaria · 2018
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  20. Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Trial

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Lenore DedeyneDepartment of Clinical and Experimental Medicine.
Mieke DeschodtDepartment of Public Health and Primary Care, KU Leuven - University of Leuven, Leuven, Belgium.
Sabine VerschuerenDepartment of Rehabilitation Sciences, KU Leuven - University of Leuven, Heverlee, Belgium.
Jos TournoyDepartment of Clinical and Experimental Medicine.
Evelien GielenDepartment of Clinical and Experimental Medicine.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrailty is an aging syndrome caused by exceeding a threshold of decline across multiple organ systems leading to a decreased resistance to stressors. Treatment for frailty focuses on multi-domain interventions to target multiple affected functions in order to decrease the adverse outcomes of frailty. No systematic reviews on the effectiveness of multi-domain interventions exist in a well-defined frail population.

objectivesThis systematic review aimed to determine the effect of multi-domain compared to mono-domain interventions on frailty status and score, cognition, muscle mass, strength and power, functional and social outcomes in (pre)frail elderly (≥65 years). It included interventions targeting two or more domains (physical exercise, nutritional, pharmacological, psychological, or social interventions) in participants defined as (pre)frail by an operationalized frailty definition.

methodsThe databases PubMed, EMBASE, CINAHL, PEDro, CENTRAL, and the Cochrane Central register of Controlled Trials were searched from inception until September 14, 2016. Additional articles were searched by citation search, author search, and reference lists of relevant articles. The protocol for this review was registered on PROSPERO (CRD42016032905).

resultsTwelve studies were included, reporting a large diversity of interventions in terms of content, duration, and follow-up period. Overall, multi-domain interventions tended to be more effective than mono-domain interventions on frailty status or score, muscle mass and strength, and physical functioning. Results were inconclusive for cognitive, functional, and social outcomes. Physical exercise seems to play an essential role in the multi-domain intervention, whereby additional interventions can lead to further improvement (eg, nutritional intervention).

conclusionEvidence of beneficial effects of multi-domain compared to mono-domain interventions is limited but increasing. Additional studies are needed, focusing on a well-defined frail population and with specific attention to the design and the individual contribution of mono-domain interventions. This will contribute to the development of more effective interventions for frail elderly.

Indexed as

Frail ElderlyAgedAgingCognitionDietary SupplementsExerciseFemaleHumansMuscle, SkeletalMuscle StrengthSocial Participationcognitionexercisehormonenutritionolder adultssocialsupplementvulnerable

Identifiers

PMID28579766
PMCPMC5448695
OpenAlexW2592012680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.