Evidence map›Paper›PMID 28579615›Full record

ArticleCellular & molecular immunology2018

Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation.

Yuan Zhang, Tae-Jin Kim, Joanna A Wroblewska, Vera Tesic, Vaibhav Upadhyay, Ralph R Weichselbaum, Alexei V Tumanov, Hong Tang, Xiaohuan Guo, Haidong Tang and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.Clinical reviews in allergy & immunology · 2020
    Review
  8. Cytokines that target immune killer cells against tumors.Cellular & molecular immunology · 2020
    Review
  9. Article
  10. Article
  11. Natural Killer Cells in the Lungs.Frontiers in immunology · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Yuan ZhangDepartment of Pathology, University of Chicago, 60637, Chicago, USA, IL.
Tae-Jin KimDepartment of Pathology, University of Chicago, 60637, Chicago, USA, IL.
Joanna A WroblewskaCommittee on Immunology, Department of Pathology, University of Chicago, 60637, Chicago, IL, USA.
Vera TesicDepartment of Pathology, University of Chicago, 60637, Chicago, USA, IL.
Vaibhav UpadhyayCommittee on Immunology, Department of Pathology, University of Chicago, 60637, Chicago, IL, USA.
Ralph R WeichselbaumDepartment of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research, University of Chicago, 60637, Chicago, IL, USA.
Alexei V TumanovDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, 78229, San Antonio, TX, USA.
Hong TangChinese Academy of Sciences Key Laboratory for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Xiaohuan GuoInstitute of Immunology, Tsinghua University School of Medicine, 100084, Beijing, China.
Haidong TangDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Yang-Xin FuDepartment of Pathology, University of Chicago, 60637, Chicago, USA, IL. yang-xin.fu@utsouthwestern.edu.
University of Chicago · USInstitute of Biophysics · CNThe University of Texas Health Science Center at San Antonio · USThe University of Texas Southwestern Medical Center · USTsinghua University · CN

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
CARDIOVASCULAR PATHOPHYSIOLOGY &BIOCHEMISTRY TRAININGT32HL007237 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 1985 to 2011
$5.0M
The role of Id2 in gut innate lymphoid cellsR01DK100427 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI FU, YANG-XIN · 2014 to 2017
$1.4M
NHLBI NIH HHS T32 HL007237NIAID NIH HHS T32 AI007090NIDDK NIH HHS R01 DK100427
6 · The paper itself

Abstract

Splenomegaly is a well-known phenomenon typically associated with inflammation. However, the underlying cause of this phenotype has not been well characterized. Furthermore, the splenomegaly phenotype seen in lymphotoxin (LT) signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils. Splenomegaly, as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues, is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice. We now present evidence that mice deficient in LTα

Indexed as

Immunity, InnateAnimalsInflammationLymphocytesLymphotoxin alpha1, beta2 HeterotrimerLymphotoxin beta ReceptorMiceMice, KnockoutMicrobiotaReceptors, Antigen, T-Cell, gamma-deltaLtbr protein, mouseLymphotoxin alpha1, beta2 HeterotrimerLymphotoxin beta ReceptorReceptors, Antigen, T-Cell, gamma-deltagerm-freelymphotoxinmicrobiotasplenomegalytype 3 innate lymphoid cells

Identifiers

PMID28579615
PMCPMC6123485
OpenAlexW2624608718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.