Could clinical photochemical internalisation be optimised to avoid neuronal toxicity?

Caitriona O'Rourke, Colin Hopper, Alexander J MacRobert, James B Phillips, Josephine H Woodhams

Open access · hybridAbstract read

In one paragraph

Article in International journal of pharmaceutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.4field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

Treatment of 3D In Vitro Tumoroids of Ovarian Cancer Using Photochemical Internalisation as a Drug Delivery Method.Biomedicines · 2023
Article
Synergy between Photodynamic Therapy and Dactinomycin Chemotherapy in 2D and 3D Ovarian Cancer Cell Cultures.International journal of molecular sciences · 2020
Article
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research.Journal of clinical medicine · 2020
Review
Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines.Cancers · 2020
Review
The intracellular redox environment modulates the cytotoxic efficacy of single and combination chemotherapy in breast cancer cells using photochemical internalisation.RSC advances · 2019
Article
Selective Cytotoxicity to HER2 Positive Breast Cancer Cells by Saporin-Loaded Nanobody-Targeted Polymeric Nanoparticles in Combination with Photochemical Internalization.Molecular pharmaceutics · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Caitriona O'RourkeDivision of Surgery & Interventional Science, University College London, London, UK; Department of Biomaterials & Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.

Colin HopperAcademic Unit of Oral and Maxillofacial Surgery, UCL Eastman Dental Institute, London, UK.

Alexander J MacRobertDivision of Surgery & Interventional Science, University College London, London, UK.

James B PhillipsDepartment of Biomaterials & Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.

Josephine H WoodhamsDivision of Surgery & Interventional Science, University College London, London, UK. Electronic address: j.woodhams@ucl.ac.uk.

University College London · GBEastman Dental Hospital · GB

Funding

Medical Research Council MR/K025422/1

6 · The paper itself

Abstract

Photochemical Internalisation (PCI) is a novel drug delivery technology in which low dose photodynamic therapy (PDT) can selectively rupture endo/lysosomes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release in the treatment of cancer. For PCI to be developed further, it is important to understand whether nerve damage is an impending side effect when treating cancers within or adjacent to nervous system tissue. Dorsal root ganglion (DRG) neurons and their associated satellite glia were subjected to PCI treatment in a 3D co-culture system following incubation with photosensitisers: meso-tetraphenylporphine (TPPS

Indexed as

Drug Delivery SystemsPhotochemotherapyBleomycinCell Line, TumorCoculture TechniquesGanglia, SpinalHumansNeoplasmsNeurogliaNeuronsPhotosensitizing AgentsPorphyrinsBleomycinmeso-tetraphenyl chlorin disulphonatePhotosensitizing AgentsPorphyrinstetraphenylporphine3D culture modelsBleomycinBleomycin (PubChem CID: 5360373)Meso-tetraphenylporphine (PubChem CID: 70186)Nervous systemPhotochemical InternalisationPhotosensitisersTetraphenylchlorin disulfonate (PubChem CID: 44177671)

Identifiers

PMID28579544

DOI10.1016/j.ijpharm.2017.05.071

PMCPMC5571751

OpenAlexW2620768271

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.