Evidence map›Paper›PMID 28579332›Full record

ArticleMolecular cell2017

Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation.

Robert Glyde, Fuzhou Ye, Vidya Chandran Darbari, Nan Zhang, Martin Buck, Xiaodong Zhang

Open access · hybridAbstract read
In one paragraph

Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Structural basis of σProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. A general mechanism for transcription bubble nucleation in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. SPARC: Structural properties associated with residue constraints.Computational and structural biotechnology journal · 2022
    Article
  14. OrpR is a σMolecular microbiology · 2021
    Article
  15. AAA+ ATPases: structural insertions under the magnifying glass.Current opinion in structural biology · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Robert GlydeSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Fuzhou YeSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Vidya Chandran DarbariSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Nan ZhangDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Martin BuckDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Xiaodong ZhangSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK. Electronic address: xiaodong.zhang@imperial.ac.uk.
Imperial College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G001278/1Biotechnology and Biological Sciences Research Council BB/H012249/1Medical Research Council MR/N006828/1Wellcome Trust
6 · The paper itself

Abstract

Gene transcription is carried out by RNA polymerases (RNAPs). For transcription to occur, the closed promoter complex (RPc), where DNA is double stranded, must isomerize into an open promoter complex (RPo), where the DNA is melted out into a transcription bubble and the single-stranded template DNA is delivered to the RNAP active site. Using a bacterial RNAP containing the alternative σ

Indexed as

Nucleic Acid DenaturationTranscription Initiation, GeneticBinding SitesCryoelectron MicroscopyDNA, Single-StrandedEscherichia coliGene Expression Regulation, BacterialKlebsiella pneumoniaeMolecular Docking SimulationNucleic Acid ConformationPromoter Regions, GeneticProtein BindingProtein ConformationRNA Polymerase Sigma 54Structure-Activity RelationshipDNA, Single-StrandedRNA Polymerase Sigma 54AAA proteinDNA distortionDNA openingRNA polymerasesigma54sigma factortranscription bubbletranscription closed complextranscription initiationtranscription intermediate complex

Identifiers

PMID28579332
PMCPMC5505868
OpenAlexW2620766554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.