Evidence map›Paper›PMID 28579099›Full record

ReviewJournal of magnetic resonance (San Diego, Calif. : 1997)2017

Rapid-scan EPR imaging.

Sandra S Eaton, Yilin Shi, Lukas Woodcock, Laura A Buchanan, Joseph McPeak, Richard W Quine, George A Rinard, Boris Epel, Howard J Halpern, Gareth R Eaton

Abstract readReview
In one paragraph

Review in Journal of magnetic resonance (San Diego, Calif. : 1997), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Reconfigurable animal bed-EPR resonator assembly for multimodal co-registration.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  2. Review
  3. Computationally efficient 4D spectral-spatial EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Rapid scan EPR: Automated digital resonator control for low-latency data acquisition.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022
    Article
  11. Advances in rapid scan EPR spectroscopy.Methods in enzymology · 2022
    Article
  12. Article
  13. Article
  14. Rapid-Scan Electron Paramagnetic Resonance of Highly Resolved Hyperfine Lines in Organic Radicals.Chemphyschem : a European journal of chemical physics and physical chemistry · 2020
    Article
  15. Article
  16. General solution for rapid scan EPR deconvolution problem.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Development of an L-band rapid scan EPR digital console.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sandra S EatonDepartment of Chemistry and Biochemistry and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
Yilin ShiDepartment of Chemistry and Biochemistry and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
Lukas WoodcockDepartment of Chemistry and Biochemistry and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
Laura A BuchananDepartment of Chemistry and Biochemistry and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
Joseph McPeakDepartment of Chemistry and Biochemistry and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
Richard W QuineSchool of Engineering and Computer Science and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
George A RinardSchool of Engineering and Computer Science and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States.
Boris EpelDepartment of Radiation and Cellular Oncology and Center for EPR Imaging In Vivo Physiology, University of Chicago, Chicago, IL 60637, United States.
Howard J HalpernDepartment of Radiation and Cellular Oncology and Center for EPR Imaging In Vivo Physiology, University of Chicago, Chicago, IL 60637, United States.
Gareth R EatonDepartment of Chemistry and Biochemistry and Center for EPR Imaging In Vivo Physiology, University of Denver, Denver, CO 80210, United States. Electronic address: geaton@du.edu.
University of Denver · USUniversity of Chicago · US

Funding

Very Low Frequency EPR Imaging in Vivo Phisiology P41 EB02034P41EB002034 · NIBIB · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2017
$16.1M
Radiation Biology of EPR Oxygen ImagesR01CA098575 · NCI · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2022
$4.5M
Preclinical Electron Paramagnetic Resonance Tumor ImagerR01CA177744 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI EATON, GARETH R · 2014 to 2019
$2.7M
NCI NIH HHS R01 CA098575NCI NIH HHS R01 CA177744NIBIB NIH HHS P41 EB002034
6 · The paper itself

Abstract

In rapid-scan EPR the magnetic field or frequency is repeatedly scanned through the spectrum at rates that are much faster than in conventional continuous wave EPR. The signal is directly-detected with a mixer at the source frequency. Rapid-scan EPR is particularly advantageous when the scan rate through resonance is fast relative to electron spin relaxation rates. In such scans, there may be oscillations on the trailing edge of the spectrum. These oscillations can be removed by mathematical deconvolution to recover the slow-scan absorption spectrum. In cases of inhomogeneous broadening, the oscillations may interfere destructively to the extent that they are not visible. The deconvolution can be used even when it is not required, so spectra can be obtained in which some portions of the spectrum are in the rapid-scan regime and some are not. The technology developed for rapid-scan EPR can be applied generally so long as spectra are obtained in the linear response region. The detection of the full spectrum in each scan, the ability to use higher microwave power without saturation, and the noise filtering inherent in coherent averaging results in substantial improvement in signal-to-noise relative to conventional continuous wave spectroscopy, which is particularly advantageous for low-frequency EPR imaging. This overview describes the principles of rapid-scan EPR and the hardware used to generate the spectra. Examples are provided of its application to imaging of nitroxide radicals, diradicals, and spin-trapped radicals at a Larmor frequency of ca. 250MHz.

Indexed as

AlgorithmsAnimalsDiagnostic ImagingElectron Spin Resonance SpectroscopyHumansMicrowavesMolecular ImagingDeconvolutionDirect detectionImagingIn vivoNitroxides

Identifiers

PMID28579099
PMCPMC5523658
OpenAlexW2620780001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.