ArticleCurrent biology : CB2017
Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration.Nature neuroscience · 2026Article
- Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Position-independent functional refinement within the vagus motor topographic map.Cell reports · 2024Article
- High-resolution Cell Transplantation in Embryonic and Larval Zebrafish.Journal of visualized experiments : JoVE · 2024Article
- Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease.International journal of molecular sciences · 2023Review
- Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators.Frontiers in cell and developmental biology · 2022Review
- Reduction of visual stimulus artifacts using a spherical tank for small, aquatic animals.Scientific reports · 2021Article
- Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction.Science advances · 2021Article
- Defective Neuronal Positioning Correlates With Aberrant Motor Circuit Function in Zebrafish.Frontiers in neural circuits · 2021Article
- Glycine Receptor Inhibition Differentially Affect Selected Neuronal Populations of the Developing Embryonic Cortex, as Evidenced by the Analysis of Spontaneous Calcium Oscillations.International journal of molecular sciences · 2020Article
- Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity.PloS one · 2020Article
- Sensorimotor Transformations in the Zebrafish Auditory System.Current biology : CB · 2019Article
- Precision electronic medicine in the brain.Nature biotechnology · 2019Review
- Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum.Frontiers in cell and developmental biology · 2019Review
- Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks.Frontiers in cellular neuroscience · 2019Review
- Article
- Brain-wide Organization of Neuronal Activity and Convergent Sensorimotor Transformations in Larval Zebrafish.Neuron · 2018Article
- Visual Experience Facilitates BDNF-Dependent Adaptive Recruitment of New Neurons in the Postembryonic Optic Tectum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Blood-brain barrier development: Systems modeling and predictive toxicology.Birth defects research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From development up to adulthood, the vertebrate brain is continuously supplied with newborn neurons that integrate into established mature circuits. However, how this process is coordinated during development remains unclear. Using two-photon imaging, GCaMP5 transgenic zebrafish larvae, and sparse electroporation in the larva's optic tectum, we monitored spontaneous and induced activity of large neuronal populations containing newborn and functionally mature neurons. We observed that the maturation of newborn neurons is a 4-day process. Initially, newborn neurons showed undeveloped dendritic arbors, no neurotransmitter identity, and were unresponsive to visual stimulation, although they displayed spontaneous calcium transients. Later on, newborn-labeled neurons began to respond to visual stimuli but in a very variable manner. At the end of the maturation period, newborn-labeled neurons exhibited visual tuning curves (spatial receptive fields and direction selectivity) and spontaneous correlated activity with neighboring functionally mature neurons. At this developmental stage, newborn-labeled neurons presented complex dendritic arbors and neurotransmitter identity (excitatory or inhibitory). Removal of retinal inputs significantly perturbed the integration of newborn neurons into the functionally mature tectal network. Our results provide a comprehensive description of the maturation of newborn neurons during development and shed light on potential mechanisms underlying their integration into a functionally mature neuronal circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.