Evidence map›Paper›PMID 28578747›Full record

Trial reportTwin research and human genetics : the official journal of the International Society for Twin Studies2017

The Decomposition of Shared Environmental Influences on Externalizing Syndromes in the Swedish Population: A Multivariate Study.

Henrik Ohlsson, Kenneth S Kendler, Paul Lichtenstein, Jan Sundquist, Kristina Sundquist

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Henrik OhlssonCenter for Primary Health Care Research,Lund University,Malmö,Sweden.
Kenneth S KendlerVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics,Karolinska Institute,STH,Sweden.
Jan SundquistCenter for Primary Health Care Research,Lund University,Malmö,Sweden.
Kristina SundquistCenter for Primary Health Care Research,Lund University,Malmö,Sweden.
Lund University · SEKarolinska Institutet · SEStanford University · USVirginia Commonwealth University · US

Funding

Genetic, Social, and Developmental Epidemiology of Drug Use DisordersR01DA030005 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENNETH SEEDMAN KENDLER, JAN O SUNDQUIST · 2010 to 2026
$7.6M
Social, Developmental and Genetic Epidemiology of Alcohol Use DisordersR01AA023534 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN, SUNDQUIST, KRISTINA · 2015 to 2023
$4.0M
NIAAA NIH HHS R01 AA023534NIDA NIH HHS R01 DA030005
6 · The paper itself

Abstract

Using information from Swedish population registries, we attempt to decompose the shared environment (C) into four subcomponents: close family, family, household, and community. Among pairs differing in their genetic and geographical/household relationships, we examine three externalizing syndromes: drug abuse (DA), criminal behavior (CB), and alcohol use disorders (AUD). The best-fitting common pathway model suggested that total estimates for C were higher for DA (21% for males and 18% for females) than for AUD (16% and 14%) and CB (17% and 10%). Concerning syndrome-specific influences in males, close family effects were stronger for CB and AUD, while community effects were stronger for DA. The two C components in between community experiences and close family experiences (family and household) were estimated to almost entirely derive from the common latent factor. In females, among the four components of C, the community experiences were just slightly above zero, while the C components referred to as the household effect were almost zero. The total close family experiences were similar and most important across syndromes were also divided into common and specific components. For all syndromes, for both males and females, the effects of additive genetic factors were 2-4 times the size of the total effect of the shared environment. Applying standard methods to novel relationships, we expand our understanding of how the shared environment contributes to individual differences in three externalizing syndromes.

Indexed as

Criminal BehaviorEnvironmentFamilyModels, GeneticRegistriesAdultAlcoholismFemaleHumansMaleMiddle AgedSubstance-Related DisordersSwedenSyndromeclose familycommunityexternalizing syndromesfamilyhouseholdshared environment

Identifiers

PMID28578747
PMCPMC5551403
OpenAlexW2622950422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.