ArticleEuropean journal of nutrition2018
Effect of increased water intake on plasma copeptin in healthy adults.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02044679 (Evaluation of Spot Urine as a Biomarker of Fluid Intake in Real Life Conditions), which is not on this map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Spot Urine as a Biomarker of Fluid Intake in Real Life Conditions
Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Investigation of possible underlying mechanisms behind water-induced glucose reduction in adults with high copeptin.Scientific reports · 2021Trial
- Trial
- Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot Study.The Journal of clinical endocrinology and metabolism · 2019Trial
- Serum sodium, tonicity, and risk of dementia in cohort and healthcare populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications.Medicina (Kaunas, Lithuania) · 2025Review
- Apparently healthy young black adults report lower total fluid intake and exhibit higher plasma copeptin than young White adults.Nutrition research (New York, N.Y.) · 2025Article
- Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health.JACC. Advances · 2025Article
- Hydration Considerations to Improve the Physical Performance and Health of Firefighters.Journal of functional morphology and kinesiology · 2024Review
- Association between Urine Specific Gravity as a Measure of Hydration Status and Risk of Type 2 Diabetes: The Kailuan Prospective Cohort Study.Nutrients · 2024Article
- Long-term health outcomes associated with hydration status.Nature reviews. Nephrology · 2024Review
- The possible role of the vasopressin system in hematopoiesis.Scientific reports · 2024Article
- The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort.PloS one · 2024Article
- Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults.The American journal of clinical nutrition · 2023Article
- Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts.EBioMedicine · 2023Article
- Article
- Online Arabic Beverage Frequency Questionnaire (ABFQ): evaluation of validity and reliability.Nutrition journal · 2023Article
- Predicting autosomal dominant polycystic kidney disease progression: review of promising Serum and urine biomarkers.Frontiers in pediatrics · 2023Review
- Analysis on fluid intake and urination behaviors among the elderly in five cities in China: a cross-sectional study.Frontiers in nutrition · 2023Article
- Personalized prediction of optimal water intake in adult population by blended use of machine learning and clinical data.Scientific reports · 2022Article
- Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease: A pooled analysis of five cohorts.Journal of internal medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin.
methodsThis trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m
resultsAt baseline, plasma copeptin was positively and significantly associated with 24-h urine osmolality (p = 0.002) and 24-h urine specific gravity (p = 0.003) but not with plasma osmolality (p = 0.18), 24-h urine creatinine (p = 0.09), and total fluid intake (p = 0.52). Over the 6-week follow-up, copeptin decreased significantly from 5.18 (3.3;7.4) to 3.90 (2.7;5.7) pmol/L (p = 0.012), while urine osmolality and urine specific gravity decreased from 591 ± 206 to 364 ± 117 mOsm/kg (p < 0.001) and from 1.016 ± 0.005 to 1.010 ± 0.004 (p < 0.001), respectively.
conclusionsAt baseline, circulating levels of copeptin were positively associated with 24-h urine concentration in healthy young subjects with various fluid intakes. Moreover, this study shows, for the first time, that increased water intake over 6 weeks results in an attenuation of circulating copeptin. CLINICAL TRIAL REGISTRATION NUMBER: NCT02044679.
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