Evidence map›Paper›PMID 28578396›Full record

ArticleScientific reports2017

Neonicotinoid-induced pathogen susceptibility is mitigated by Lactobacillus plantarum immune stimulation in a Drosophila melanogaster model.

Brendan A Daisley, Mark Trinder, Tim W McDowell, Hylke Welle, Josh S Dube, Sohrab N Ali, Hon S Leong, Mark W Sumarah, Gregor Reid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. Review
  3. Insect immunity in the Anthropocene.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  4. Role of Lactic Acid Bacteria in Insecticide Residue Degradation.Probiotics and antimicrobial proteins · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Impact of Pesticides on Human Health in the Last Six Years in Brazil.International journal of environmental research and public health · 2022
    Review
  18. Endocrine Disruptors and Prostate Cancer.International journal of molecular sciences · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Brendan A DaisleyCanadian R&D Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, N6A 4V2, Ontario, Canada.
Mark TrinderCanadian R&D Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, N6A 4V2, Ontario, Canada.ORCID 0000-0001-8447-2897
Tim W McDowellLondon Research and Development Center, Agriculture and Agri-Food Canada, London, N5V 3V3, Canada.
Hylke WelleCanadian R&D Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, N6A 4V2, Ontario, Canada.
Josh S DubeDepartment of Microbiology and Immunology, The University of Western Ontario, London, N6A 5C1, Canada.
Sohrab N AliDepartment of Microbiology and Immunology, The University of Western Ontario, London, N6A 5C1, Canada.
Hon S LeongDepartment of Microbiology and Immunology, The University of Western Ontario, London, N6A 5C1, Canada.
Mark W SumarahLondon Research and Development Center, Agriculture and Agri-Food Canada, London, N5V 3V3, Canada.
Gregor ReidCanadian R&D Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, N6A 4V2, Ontario, Canada. gregor@uwo.ca.ORCID 0000-0001-9658-5696
Western University · CAAgriculture and Agri-Food Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pesticides are used extensively in food production to maximize crop yields. However, neonicotinoid insecticides exert unintentional toxicity to honey bees (Apis mellifera) that may partially be associated with massive population declines referred to as colony collapse disorder. We hypothesized that imidacloprid (common neonicotinoid; IMI) exposure would make Drosophila melanogaster (an insect model for the honey bee) more susceptible to bacterial pathogens, heat stress, and intestinal dysbiosis. Our results suggested that the immune deficiency (Imd) pathway is necessary for D. melanogaster survival in response to IMI toxicity. IMI exposure induced alterations in the host-microbiota as noted by increased indigenous Acetobacter and Lactobacillus spp. Furthermore, sub-lethal exposure to IMI resulted in decreased D. melanogaster survival when simultaneously exposed to bacterial infection and heat stress (37 °C). This coincided with exacerbated increases in TotA and Dpt (Imd downstream pro-survival and antimicrobial genes, respectively) expression compared to controls. Supplementation of IMI-exposed D. melanogaster with Lactobacillus plantarum ATCC 14917 mitigated survival deficits following Serratia marcescens (bacterial pathogen) septic infection. These findings support the insidious toxicity of neonicotinoid pesticides and potential for probiotic lactobacilli to reduce IMI-induced susceptibility to infection.

Indexed as

Disease SusceptibilityAnimalsAnimals, Genetically ModifiedBiomarkersDisease Models, AnimalDrosophila melanogasterGram-Positive Bacterial InfectionsHost-Pathogen InteractionsInsecticidesLactiplantibacillus plantarumNeonicotinoidsNitro CompoundsBiomarkersimidaclopridInsecticidesNeonicotinoidsNitro Compounds

Identifiers

PMID28578396
PMCPMC5457429
OpenAlexW2619076243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.