ArticleScientific reports2017
Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 171 citations in OpenAlex.
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- Functional hydrogel biomaterials for urological diagnosis and treatment-design strategies and application progress: a review.Journal of materials science. Materials in medicine · 2026Review
- Simultaneous Cross-Linking and Nanoparticle Anchoring by Dialdehyde Cellulose in Injectable Composite Chitosan/Polypyrrole Hydrogels.ACS applied bio materials · 2026Article
- Liposomal Nanosystems Versus Hydrogels in the Prevention and Treatment of Metabolic Diseases.Gels (Basel, Switzerland) · 2025Review
- Hyaluronic Acid/Chitosan/Glycerophosphate-Based In Situ-Forming Hydrogel for Accelerated Wound Healing.Gels (Basel, Switzerland) · 2025Article
- Hyaluronic Acid: Production Strategies, Gel-Forming Properties, and Advances in Drug Delivery Systems.Gels (Basel, Switzerland) · 2025Review
- Design and Evaluation of a Crosslinked Chitosan-Based Scaffold Containing Hyaluronic Acid for Articular Cartilage Reconstruction.Molecules (Basel, Switzerland) · 2025Article
- Highly Absorbent Ultrafast Self-Gelling Starch Microparticles for Robust Wet-Tissue Adhesion and Instant Hemostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fabrication of 3-Dimensional-Printed Bilayered Scaffold Carboxymethyl Chitosan/Oxidized Xanthan Gum, Biphasic Calcium Phosphate for Osteochondral Regeneration.Biomaterials research · 2025Article
- Preparation and Characterization of Photo-Cross-Linkable Methacrylated Silk Fibroin and Methacrylated Hyaluronic Acid Composite Hydrogels.Biomacromolecules · 2024Article
- Promotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells.International journal of molecular sciences · 2024Article
- Unraveling and Harnessing the Immune Response at the Cell-Biomaterial Interface for Tissue Engineering Purposes.Advanced healthcare materials · 2024Review
- NIR-Responsive injectable hydrogel cross-linked by homobifunctional PEG for photo-hyperthermia of melanoma, antibacterial wound healing, and preventing post-operative adhesion.Materials today. Bio · 2024Article
- Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review.Biomaterials research · 2024Article
- Exploring the Formulation and Approaches of Injectable Hydrogels Utilizing Hyaluronic Acid in Biomedical Uses.Advances in pharmacological and pharmaceutical sciences · 2024Review
- Biomaterials for immunomodulation in wound healing.Regenerative biomaterials · 2024Review
- Evaluation of the Effect of Honey-Containing Chitosan/Hyaluronic Acid Hydrogels on Wound Healing.Gels (Basel, Switzerland) · 2023Article
- 3D bio-printed hydrogel inks promoting lung cancer cell growth in a lab-on-chip culturing platform.Mikrochimica acta · 2023Article
- Abdominal wall hernia repair: from prosthetic meshes to smart materials.Materials today. Bio · 2023Review
- Hyaluronic Acid-Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release.Gels (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abdominal wall defect caused by open abdomen (OA) or abdominal trauma is a serious issue since it induces several clinical problems. Although a variety of prosthetic materials are commonly employed, complications occur including host soft tissue response, fistula formation and chronic patient discomfort. Recently, abundant natural polymers have been used for injectable hydrogel synthesis in tissue regeneration. In this study, we produced the chitosan - hyaluronic acid (CS/HA) hydrogel and investigated its effects on abdominal tissue regeneration. The physical and biological properties of the hydrogel were demonstrated to be suitable for application in abdominal wounds. In a rat model simulating open abdomen and large abdominal wall defect, rapid cellular response, sufficient ECM deposition and marked neovascularization were found after the application of the hydrogel, compared to the control group and fibrin gel group. Further, the possible mechanism of these findings was studied. Cytokines involved in angiogenesis and cellular response were increased and the skew toward M2 macrophages credited with the functions of anti-inflammation and tissue repair was showed in CS/HA hydrogel group. These findings suggested that CS/HA hydrogel could prevent the complications and was promising for abdominal tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.