ArticleMedical science monitor : international medical journal of experimental and clinical research2017
Association of Thyroid-Stimulating Hormone Levels with Microvascular Complications in Type 2 Diabetes Patients.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes.BioMed research international · 2020Trial
- Association between thyroid hormones and diabetic kidney disease in euthyroid type 2 diabetes mellitus patients.Frontiers in endocrinology · 2026Article
- Higher Prevalence of Thyroid Dysfunction in Type 2 Diabetes Mellitus: Effects on Glycemic Control, Diabetic Complications and Comorbidities.Medicina (Kaunas, Lithuania) · 2025Article
- Association between thyroid stimulating hormone levels and nonproliferative diabetic retinopathy: a cross-sectional study.BMC endocrine disorders · 2025Article
- Association between sensitivity to thyroid hormone indices and type 2 diabetic microvascular complications in euthyroid patients.Scientific reports · 2024Article
- Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- PROGNOSTIC VALUES OF LIPID PANEL DATA FOR MACROVASCULAR COMPLICATION DEVELOPMENT IN TYPE 2 DIABETIC PATIENTS WITH COMORBID THYROID DYSFUNCTION.Acta clinica Croatica · 2024Article
- Association between thyroid hormones and diabetic kidney disease in Chinese adults.BMC endocrine disorders · 2023Article
- Assessment of the association between genetic factors regulating thyroid function and microvascular complications in diabetes: A two-sample Mendelian randomization study in the European population.Frontiers in endocrinology · 2023Article
- The effect of Central and peripheral thyroid resistance indices on diabetic retinopathy: a study of hospitalized euthyroid patients with T2DM in China.Annals of medicine · 2023Article
- Serum Antithyroglobulin Antibody Levels Are Associated with Diabetic Retinopathy among Euthyroid Type 2 Diabetes Patients: A Hospital-Based, Retrospective Study.Journal of diabetes research · 2022Article
- Does autoimmune hypothyroidism increase the risk of neurovascular complications in type 1 diabetes?Journal of endocrinological investigation · 2020Article
- Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case-Control Study.International journal of general medicine · 2020Article
- The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2019Article
- Observational
- Thyroid stimulating hormone and free triiodothyronine are valuable predictors for diabetic nephropathy in patient with type 2 diabetes mellitus.Annals of translational medicine · 2018Article
- Article
- Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes.Scientific reports · 2018Article
- Relationship between Thyroid Function and Kidney Function in Patients with Type 2 Diabetes.International journal of endocrinology · 2018Article
- A cross-sectional cohort study with microvascular complications in patients with type 2 diabetes with and without hypothyroidism.Cardiovascular journal of AfricaObservational
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8 authors.
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Abstract
BACKGROUND Subclinical hypothyroidism (SCH) is typically featured by elevated serum concentration of thyroid-stimulating hormone (TSH). This study aimed to determine the relationship between TSH levels and microvascular complications in type 2 diabetes patients. MATERIAL AND METHODS A total of 860 type 2 diabetes patients were enrolled in this cross-sectional study. Subjects were evaluated for anthropometric measurements, thyroid function, diabetic retinopathy, and diabetic kidney disease. TSH was divided into 3 levels: 0.27-2.49 mU/l, 2.5-4.2 mU/l, and >4.2 mU/l. RESULTS Among the participants, 76 subjects (8.8%) were diagnosed with subclinical hypothyroidism (SCH) (male: 6.6% and female: 11.8%). The prevalence of diabetic retinopathy did not differ among the groups (P=0.259). Of the 860 type 2 diabetic subjects, we further excluded invalid or missing data. Therefore, 800 and 860 subjects were included in our study of diabetic retinopathy (DR) and diabetic kidney disease (DKD), respectively. The frequencies of microalbuminuria and macroalbuminuria differed significantly among the different groups. The frequency of DKD was significantly different among the 3 groups (P=0.001) and was higher in subjects with higher TSH levels. After an adjustment for confounding variables, TSH levels were significantly associated with DKD (P<0.001). When compared with subjects with TSH 0.27-2.49 mU/l, the frequency of DKD was higher in subjects with TSH >4.20 mU/l (OR 1.531, 95% CI 1.174-1.997) and with TSH 2.50-4.20 mU/l (OR 1.579, 95% CI 1.098-2.270). However, TSH levels was not significantly correlated with DR (P=0.126). CONCLUSIONS Type 2 diabetic patients with higher TSH values had a higher prevalence of DKD.
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