ArticleMedicina oral, patologia oral y cirugia bucal2017
Accuracy of cotinine serum test to detect the smoking habit and its association with periodontal disease in a multicenter study.
Article in Medicina oral, patologia oral y cirugia bucal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Associations of Serum GIP, GLP-1, and DPP-4 with Metabolic and Hormonal Profiles and Tobacco Exposure in Women with Polycystic Ovary Syndrome.International journal of molecular sciences · 2025Article
- Maternal Vascular Adaptation in High-Risk Pregnancies: Effects of Early Smoking Cessation on Hemodynamic and Endothelial Function.International journal of molecular sciences · 2025Article
- Association Between Blood Benzene Levels and Periodontal Disease in a Nationally Representative Adult U.S. Population.International journal of environmental research and public health · 2025Article
- The Estimation of Cementoenamel Junction Crestal Bone Distance in Mandibular Anterior Teeth.Clinical, cosmetic and investigational dentistry · 2025Article
- Article
- High cotinine levels as an associated factor with frailty status in older adults: evidence from the NHANES study.BMC geriatrics · 2024Article
- Factors Associated with the Extent of Clinical Attachment Loss in Periodontitis: A Multicenter Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- Effect of Smoke Exposure on Gene Expression in Bone Healing around Implants Coated with Nanohydroxyapatite.Nanomaterials (Basel, Switzerland) · 2022Article
- Demographic and Habitual Factors of Periodontal Disease among South Indian Adults.International journal of environmental research and public health · 2021Article
- Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011-2012.International journal of environmental research and public health · 2020Article
- Effects of Nicotine Gum Administration on Vision (ENIGMA-Vis): Study Protocol of a Double-Blind, Randomized, and Controlled Clinical Trial.Frontiers in human neuroscience · 2020Article
- Tobacco smoking and associated factors in human immunodeficiency virus-infected adults attending human immunodeficiency virus clinics in the Western Cape province, South Africa.Southern African journal of HIV medicine · 2020Article
- Periodontal Disease Status among Adults from South Africa-Prevalence and Effect of Smoking.International journal of environmental research and public health · 2019Article
- Association of passive smoking with dental caries and salivary biomarkers among 5-10 years old children of Muradnagar, Ghaziabad.Journal of family medicine and primary care · 2019Article
- Effect of tobacco on periodontal disease and oral cancer.Tobacco induced diseases · 2019Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe validity of the surveys on self-reported smoking status is often questioned because smokers underestimate cigarette use and deny the habit. It has been suggested that self-report should be accompanied by cotinine test. This report evaluates the usefulness of serum cotinine test to assess the association between smoking and periodontal status in a study with a large sample population to be used in studies with other serum markers in epidemiologic and periodontal medicine researches. MATERIAL AND
methods578 patients who were part of a multicenter study on blood biomarkers were evaluated about smoking and its relation to periodontal disease. Severity of periodontal disease was determinate using clinical attachment loss (CAL). Smoking was assessed by a questionnaire and a blood sample drawn for serum cotinine determination.
resultsThe optimal cut-off point for serum cotinine was 10 ng/ml. Serum cotinine showed greater association with severity of CAL than self-report for mild-moderate CAL [OR 2.03 (CI95% 1.16-3.53) vs. OR 1.08 (CI95% 0.62-1.87) ] advanced periodontitis [OR 2.36 (CI95% 1.30- 4.31) vs. OR 2.06 (CI95% 0.97-4.38) ] and extension of CAL > 3 mm [ OR 1.78 (CI95% 1.16-1.71) vs. 1.37 (CI95% 0.89-2.11)]. When the two tests were evaluated together were not shown to be better than serum cotinine test.
conclusionsSelf-reported smoking and serum cotinine test ≥ 10ng/ml are accurate ,complementary and more reliable methods to assess the patient's smoking status and could be used in studies evaluating serum samples in large population and multicenter studies. CLINICAL RELEVANCE: The serum cotinine level is more reliable to make associations with the patient's periodontal status than self-report questionnaire and could be used in multicenter and periodontal medicine studies.
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