ArticleJournal of nutrigenetics and nutrigenomics2017
Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.
Article in Journal of nutrigenetics and nutrigenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Association of Lifestyle-Induced Weight Loss With Gene Expression in Subcutaneous Adipose Tissue in Metabolic Syndrome.Journal of diabetes · 2025Trial
- Association between Single Nucleotide Polymorphisms and Weight Reduction in Behavioural Interventions-A Pooled Analysis.Nutrients · 2021Trial
- Serum SH2B1 and SULT1A2 in relation to adiposity and early weight-loss response: a hypothesis-generating study.Frontiers in endocrinology · 2026Article
- Review
- Proteomic changes upon treatment with semaglutide in individuals with obesity.Nature medicine · 2025Article
- Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Perilipins at a glance.Journal of cell science · 2022Article
- Effects of Four Lipid Metabolism-Related Polymorphisms on Body Composition Improvements After 12 Weeks of High-Intensity Interval Training and Dietary Energy Restriction in Overweight/Obese Adult Women: A Pilot Study.Frontiers in physiology · 2021Article
- Precision medicine in adult and pediatric obesity: a clinical perspective.Therapeutic advances in endocrinology and metabolism · 2019Review
- Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight loss success is determined by genetic factors, which may differ according to treatment strategy.
methodsFrom a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited. At baseline, a blood sample was drawn for DNA isolation. Genotypes were determined for 30 polymorphisms in 25 candidate genes. The association between genotypes and weight loss was assessed after 3 months (short-term) and after 12 months of treatment (long-term). Weight loss was categorized as ≥5% or <5% of initial weight.
resultsThe G/G genotype of PLIN1 (rs2289487) and PLIN1 (rs2304795), the T/T genotype of PLIN1 (rs1052700), and the C/C genotype of MMP2 predicted ≥5% weight loss in the first 3 months. The C/G-G/G genotype of PPARγ (rs1801282) and the T/C genotype of TIMP4 (rs3755724) predicted ≥5% weight loss after 12 months. Subjects with the combination of PPARγ (rs1801282) C/G-G/G and TIMP4 (rs3755724) T/C lost even more weight.
conclusionPolymorphisms in genes related to regulation of fat storage and structural adaptation of the adipocytes are predictors for weight loss success with different genes being relevant for short-term and long-term weight loss success.
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