Evidence map›Paper›PMID 28578314›Full record

ArticleThe Journal of biological chemistry2017

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites.

John G Mina, Julie K Thye, Amjed Q I Alqaisi, Louise E Bird, Robert H Dods, Morten K Grøftehauge, Jackie A Mosely, Steven Pratt, Hosam Shams-Eldin, Ralph T Schwarz and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. TheBiology open · 2019
    Article
  8. Sphingolipid biosynthesis in man and microbes.Natural product reports · 2018
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

John G MinaDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.
Julie K ThyeDepartment of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Amjed Q I AlqaisiDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom; Biology Department, College of Science, University of Baghdad, Baghdad 10071, Iraq.
Louise E BirdOxford Protein Production Facility UK, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0FA, United Kingdom.
Robert H DodsDepartment of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Morten K GrøftehaugeDepartment of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Jackie A MoselyDepartment of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Steven PrattDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.
Hosam Shams-EldinInstitut für Virologie, Zentrum für Hygiene und Infektionsbiologie, Philipps-Universität Marburg, 35043 Marburg, Germany.
Ralph T SchwarzInstitut für Virologie, Zentrum für Hygiene und Infektionsbiologie, Philipps-Universität Marburg, 35043 Marburg, Germany.
Ehmke PohlDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom; Department of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Paul W DennyDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom. Electronic address: p.w.denny@durham.ac.uk.
Durham University · GBPhilipps University of Marburg · DERutherford Appleton Laboratory · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D52396X/1Biotechnology and Biological Sciences Research Council BB/M024156/1Medical Research Council MR/K018779/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, MolecularPhylogenyAmino Acid SequenceCatalytic DomainComputational BiologyConserved SequenceDimerizationEndoplasmic ReticulumGene DeletionGene DuplicationGene Transfer, HorizontalIsoenzymesPeptide FragmentsProtein ConformationProtein Interaction Domains and MotifsProtein TransportIsoenzymesPeptide FragmentsProtozoan ProteinsRecombinant Fusion ProteinsSerine C-PalmitoyltransferaseApicomplexaevolutionparasite metabolismserine palmitoyltransferasesmall angle X-ray scatteringsphingolipidToxoplasma gondii

Identifiers

PMID28578314
PMCPMC5519370
OpenAlexW2620694916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.