Evidence map›Paper›PMID 28578226›Full record

ArticleDrug and alcohol dependence2017

Cocaine use may modify HIV/ART-associated myocardial steatosis and hepatic steatosis.

Shenghan Lai, Gary Gerstenblith, Richard D Moore, David D Celentano, David A Bluemke, Glenn Treisman, Chia-Ying Liu, Ji Li, Shaoguang Chen, Thomas Kickler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Expert Panel Review on Nonalcoholic Fatty Liver Disease in Persons With Human Immunodeficiency Virus.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Cocaine use may induce telomere shortening in individuals with HIV infection.Progress in neuro-psychopharmacology & biological psychiatry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shenghan LaiDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: slai@jhmi.edu.
Gary GerstenblithDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Richard D MooreDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
David D CelentanoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
David A BluemkeDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, USA.
Glenn TreismanDepartment of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Chia-Ying LiuDepartment of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, USA.
Ji LiDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Shaoguang ChenDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Thomas KicklerDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Hong LaiDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USNational Institutes of Health Clinical Center · US

Funding

Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular DiseaseU01DA040325 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LAI, SHENGHAN · 2016 to 2024
$12.7M
Subclinical Atherosclerosis in HIV plus Black Cocaine UsersR01DA012777 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 1999 to 2014
$8.2M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
HIV Infection, Cocaine Use and Coronary Artery Disease in HIV+ African AmericansR01DA025524 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2008 to 2012
$3.8M
HIV, Cocaine &Regional Left Ventricular DysfunctionR01DA015020 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2002 to 2006
$3.4M
NIDA NIH HHS R01 DA012777NIDA NIH HHS R01 DA015020NIDA NIH HHS R01 DA025524NIDA NIH HHS U01 DA040325
6 · The paper itself

Abstract

backgroundIt has been recognized that myocardial and hepatic steatosis may be more prevalent in HIV-infected individuals on antiretroviral therapy (ART); however, factors associated with these conditions have not been thoroughly investigated. The goals of this study were (1) to identify the risk factors for myocardial and hepatic steatosis in HIV-infected African Americans (AAs) and explore whether ART use is independently associated with myocardial and hepatic steatosis, and (2) to examine whether and how cocaine use influences any associations of ART use with myocardial and hepatic steatosis.

methodsBetween June 2010 and December 2013, 220 HIV-infected AAs in Baltimore, Maryland, were enrolled in a study investigating HIV/ART-associated myocardial and hepatic damage. Proton magnetic resonance spectroscopy was performed to quantify myocardial and hepatic triglyceride contents. Sociodemographic, medical and laboratory data were also obtained. Robust regression model was employed to perform primary statistical analysis.

resultsRobust regression analyses showed that (1) duration of protease inhibitor (PI) use was independently associated with myocardial and hepatic triglyceride contents, (2) duration of PI use was independently associated with myocardial triglyceride in cocaine users (p=0.025), but not in cocaine never-users (p=0.84), and (3) duration of PI use was independently associated with hepatic triglyceride in cocaine users, but not in cocaine never-users (p=0.52).

conclusionsCocaine use may trigger/exacerbate the toxicity of PI in ART-associated myocardial and hepatic steatosis, suggesting that cocaine abstinence/reduced use may retard these ART-associated comorbidities. Clinical trials should be conducted to examine whether reduced cocaine use improves HIV/AIDS-associated myocardial and hepatic steatosis.

Indexed as

Black or African AmericanAdultAntiretroviral Therapy, Highly ActiveBaltimoreCocaine-Related DisordersCross-Sectional StudiesFatty LiverFemaleHIV InfectionsHumansMaleMiddle AgedMyocardiumProton Magnetic Resonance SpectroscopyRisk FactorsAfrican AmericansAntiretroviral therapyCocaine useHepatic triglyceride contentHIV infectionMyocardial triglyceride content

Identifiers

PMID28578226
PMCPMC7028311
OpenAlexW2619561261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.