Evidence map›Paper›PMID 28578159›Full record

ArticleThe Journal of pediatrics2017

Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection.

Julia L Hurwitz, Bart G Jones, Rhiannon R Penkert, Shane Gansebom, Yilun Sun, Li Tang, Anna M Bramley, Seema Jain, Jonathan A McCullers, Sandra R Arnold

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Nuclear Receptors, Ligands and the Mammalian B Cell.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia L HurwitzDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center (UTHSC), Memphis, TN.
Bart G JonesDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN.
Rhiannon R PenkertDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN.
Shane GansebomDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN.
Yilun SunDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.
Li TangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.
Anna M BramleyInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA.
Seema JainInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA.
Jonathan A McCullersDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN; Department of Pediatrics, UTHSC, Memphis, TN; Le Bonheur Children's Hospital, Memphis, TN.
Sandra R ArnoldDepartment of Pediatrics, UTHSC, Memphis, TN; Le Bonheur Children's Hospital, Memphis, TN.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Incidence and etiology of pneumonia in childrenU18IP000489 · IP · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MCCULLERS, JONATHAN A · 2011 to 2013
$937k
NCI NIH HHS P30 CA021765NCIRD CDC HHS U18 IP000489
6 · The paper itself

Abstract

Retinol binding protein and vitamin D were measured in children aged <5 years hospitalized with lower respiratory tract infection and respiratory syncytial virus and/or human metapneumovirus detections. Low vitamin levels were observed in 50% of the children and were associated with significantly elevated risk of the need for intensive care unit admission and invasive mechanical ventilation.

Indexed as

ChildChild, PreschoolFemaleHospitalizationHumansInfantIntensive Care Units, PediatricMaleMetapneumovirusParamyxoviridae InfectionsPneumonia, ViralRespiration, ArtificialRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRetinol-Binding ProteinsVitamin DRetinol-Binding ProteinsVitamin Dintensive caremechanical ventilationparamyxovirusrespiratory infectionrespiratory tractvitamin levels

Identifiers

PMID28578159
PMCPMC5588918

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.