Evidence map›Paper›PMID 28577822›Full record

ArticleBrain and language2017

Genome-wide association study of language performance in Alzheimer's disease.

Kacie D Deters, Kwangsik Nho, Shannon L Risacher, Sungeun Kim, Vijay K Ramanan, Paul K Crane, Liana G Apostolova, Andrew J Saykin, Alzheimer's Disease Neuroimaging Initiative

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and language, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04482179 (A Phase II, Randomized, Blinded Study of Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for the Treatment of Chronic Aphasia - Alzheimer Disease Sub-study), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04482179 phase1completednot on this mapstarted 2020, after this paper: background citation

A Phase II, Randomized, Blinded Study of Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for the Treatment of Chronic Aphasia - Alzheimer Disease Sub-study

TypeinterventionalSponsorUniversity of PennsylvaniaRan2020 to 2024Enrolled23ConditionsAlzheimer DiseaseArmsActive TMS, CILT, Sham TMS
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kacie D DetersCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA; Program in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Kwangsik NhoCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Sungeun KimCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Vijay K RamananCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Liana G ApostolovaCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: asaykin@iupui.edu.
Alzheimer's Disease Neuroimaging Initiative
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USUniversity of Washington · US

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
Improving Cognitive Outcome Precision & Responsiveness with Modern PsychometricsR01AG029672 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K · 2007 to 2021
$7.0M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT: NEUROLOGICAL DISORDERS:ALZ, PDC06RR020128 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FIFE, ROSE S · 2004 to 2004
$3.7M
Genetic architecture of memory and executive functioning in Alzheimer's diseaseR01AG042437 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K · 2014 to 2017
$2.7M
Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex DiseaseR01LM012535 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI NHO, KWANGSIK TIMOTHY · 2017 to 2021
$1.7M
Bioinformatics Strategies for Multidimensional Brain Imaging GeneticsR01LM011360 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI MOORE, JASON H., SAYKIN, ANDREW J · 2012 to 2015
$1.4M
Imaging and genetic biomarkers for Alzheimer's diseaseR01AG040770 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI APOSTOLOVA, LIANA G · 2012 to 2016
$1.4M
CIHRNCATS NIH HHS UL1 TR001108NCRR NIH HHS C06 RR020128NCRR NIH HHS S10 RR027710NCRR NIH HHS UL1 RR025761NIA NIH HHS K01 AG049050NIA NIH HHS K02 AG048240NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG029672NIA NIH HHS R01 AG040770NIA NIH HHS R01 AG042437NIA NIH HHS R36 AG053445NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904NLM NIH HHS K99 LM011384NLM NIH HHS R00 LM011384NLM NIH HHS R01 LM011360NLM NIH HHS R01 LM012535
6 · The paper itself

Abstract

Language impairment is common in prodromal stages of Alzheimer's disease (AD) and progresses over time. However, the genetic architecture underlying language performance is poorly understood. To identify novel genetic variants associated with language performance, we analyzed brain MRI and performed a genome-wide association study (GWAS) using a composite measure of language performance from the Alzheimer's Disease Neuroimaging Initiative (ADNI; n=1560). The language composite score was associated with brain atrophy on MRI in language and semantic areas. GWAS identified GLI3 (GLI family zinc finger 3) as significantly associated with language performance (p<5×10

Indexed as

Genome-Wide Association StudyLanguageAgedAlzheimer DiseaseBrainFemaleHumansKruppel-Like Transcription FactorsMagnetic Resonance ImagingMaleNerve Tissue ProteinsNeuroimagingProdromal SymptomsReceptors, GlutamateZinc Finger Protein Gli3GLI3 protein, humanKruppel-Like Transcription FactorsNerve Tissue ProteinsReceptors, GlutamateZinc Finger Protein Gli3Alzheimer’s diseaseGLI3GWASLanguage performanceNeuroimaging

Identifiers

PMID28577822
PMCPMC5583024
OpenAlexW2621078918

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.